The aim of studying and bibliography

The main aim of study: Acquainting with stages of the drug design and methods of isolation and synthesis.

The general information about the module: The lecture and the laboratory are in the second semester during 30 hr of lectures and 30 hr of the laboratory. It is ending with an exam.

Teaching materials: Instrukcje do ćwiczeń laboratoryjnych dostępne ze strony domowej koordynatora

Bibliography required to complete the module

Bibliography used during lectures

1	Patrick L. G.,	Chemia Leków. Krótkie wykłady PWN., 2004 2.	PWN., 2004.	2004
2	Silverman R.B.,	Chemia Organiczna w Projektowaniu Leków	WNT Warszawa.	2004
3	Kieć-Kononowicz K. (red)	Wybrane zagadnienia z metod poszukiwania i otrzymywania środków leczniczych	Wydawnictwo UJ.	2006
4	Parick L. G.	Chemia Medyczna. Podstawowe zagadnienia.	WNT.	2003

Bibliography used during classes/laboratories/others

1

Instrukcje wewnętrzne Katedry

.

Bibliography to self-study

1	Binecki S	Preparatyka środkow leczniczych	PZWL Warszawa.	1983
2	Tkaczyński T., Tkaczyńska D	Synteza i technologia chemiczna leków	PZWL Warszawa.	1984
3	Tułecki J.	Technologia Srodków leczniczych	PZWL Warszawa.	1978

Basic requirements in category knowledge/skills/social competences

Formal requirements: Registration for the given semester.

Basic requirements in category knowledge: Basic knowledge in the, general chemistry, physical and analytical chemistry, and organic chemistry.

Basic requirements in category skills: Ability of choice method of the synthesis of organic compounds, showing methods of analysis.

Basic requirements in category social competences: Ability of the cooperation and the work in the group.

Module outcomes

MEK	The student who completed the module	Types of classes / teaching methods leading to achieving a given outcome of teaching	Methods of verifying every mentioned outcome of teaching	Relationships with KEK	Relationships with PRK
01	Student is able to choose and to apply basic techniques of receiving the medical product/drug.	Lecture, laboratory	Pass laboratory credit, pass lecture material credit	K_W01+ K_U03+ K_U06+ K_U09+	P7S_UK P7S_UO P7S_UW P7S_WG
02	Student knows basic and special techniques of the quantitative analysis and quality of medical product.	lecture, laboratory	Pass laboratory credit, pass lecture material credit	K_W01+ K_U03+ K_U06+ K_U09+	P7S_UK P7S_UO P7S_UW P7S_WG
03	Can qualify a pharmacologically active compound to a specific group of drugs by the presence of a pharmacophore group.	lecture, laboratory	exam part written	K_W01+ K_U03+ K_U06+ K_U09+	P7S_UK P7S_UO P7S_UW P7S_WG
04	Is able to plan the preparation of a selected compound with potential pharmacological activity in the mode of synthesis and retrosynthesis	lecture	exam part written	K_W01+ K_U03+ K_U06+ K_U09+	P7S_UK P7S_UO P7S_UW P7S_WG

Attention: Depending on the epidemic situation, verification of the achieved learning outcomes specified in the study program, in particular credits and examinations at the end of specific classes, can be implemented remotely (real-time meetings).

The syllabus of the module

Sem.	TK	The content	realized in	MEK
2	TK01	Drug from the idea for the implementation: Leading Structure - search; relation between the structure and the activity of the drug; Pharmacokinetics; QSAR; Combinatorial Synthesis. Laboratory: chosen methods of synthesis of drugs.	MEK01, MEK02	MEK01 MEK02
2	TK02	Definition of the medicine/drug, stages of seeking the medicine, choice of the site of action of the medicine, choice of the biological assay, seeking the leading structure.	W01,W02,W03	MEK01 MEK02
2	TK03	Synthesis on the solid phase - bases and assumptions.	W04	MEK01 MEK02
2	TK04	Combinatorial synthesis - idea, methods.	W05, W06	MEK01 MEK02
2	TK05	Isolation and purification the active ingredient, elucidation the structure of the active compound.	W07, W08	MEK01 MEK02
2	TK06	Pharmacophore, isostere - definition, examples.	W09, W10	MEK01 MEK02
2	TK07	Synthesis of the most popular drugs e.g. prazole, antibiotics, betablockers and statins.	W11, W12	MEK01 MEK02
2	TK08	Elements of strategy of planning the synthesis of new potential drugs. The most popular types of the reaction used in the synthesis of medicines/drugs in including analysis of the applied synthesis in the pharmaceutical industry.	W13, W14	MEK01 MEK02
2	TK09	Written passing the subject.	W15	MEK01 MEK02
2	TK10	Performing five laboratory exercises from the area of the isolation, the synthesis and analysis of medical products.	L01-L06	MEK01 MEK02

The student's effort

The type of classes	The work before classes	The participation in classes	The work after classes
Lecture (sem. 2)		contact hours: 30.00 hours/sem.	complementing/reading through notes: 2.00 hours/sem. Studying the recommended bibliography: 5.00 hours/sem. Others: 5.00 hours/sem.
Laboratory (sem. 2)	The preparation for a Laboratory: 3.00 hours/sem. The preparation for a test: 5.00 hours/sem. Others: 1.50 hours/sem.	contact hours: 30.00 hours/sem.	Finishing/Making the report: 3.00 hours/sem. Others: 1.00 hours/sem.
Advice (sem. 2)	The preparation for Advice: 0.50 hours/sem.	The participation in Advice: 3.00 hours/sem.
Exam (sem. 2)	The preparation for an Exam: 10.00 hours/sem.	The written exam: 2.00 hours/sem. Others: 3.00 hours/sem.

The way of giving the component module grades and the final grade

The type of classes	The way of giving the final grade
Lecture	Written credit of lecture material. The student is obtaining 15 questions from material of lecture scored 0,0-1.0 pt/every question - generally 15 pt of the 100%). Evaluations: 60-67 % evaluation 3.0; 68-75 % evaluation 3.5; 76-83 % evaluation 4.0; 84-91 % evaluation 4.5; 92-100 % evaluation 5.0.
Laboratory	Evaluation of the laboratory (OL): arithmetic mean from the arithmetic mean of every practical session. The arithmetic mean of every practical session has components a) preparation for classes, b) execution, c) taking notes and a written report.
The final grade	Final evaluation (K): K = 0.4 wL + 0.6 wZ: where L and from is denoting the positive assessment appropriately from the laboratory and the lecture, w-współczynnik date taking into account of ranking, w = 1.0 the first term, w = 0.9 the second term, w = 0.8 the third term.

Sample problems

Required during the exam/when receiving the credit
(-)

Realized during classes/laboratories/projects
(-)

Others
(-)

Can a student use any teaching aids during the exam/when receiving the credit : no

The contents of the module are associated with the research profile: yes

1	G. Groszek; A. Kij; K. Kuś; J. Suraj-Prażmowska; M. Walczak	A preliminary metabolites identification of a novel compound with β-adrenolytic activity	2021
2	A. Bajek-Bil; N. Buszta; W. Depa; G. Groszek; P. Guńka; J. Zachara	Chirality transfer in the synthesis of 2,3-dihydro-1,4-dithiine derivatives	2020
3	A. Bajek; N. Buszta; W. Depa; G. Groszek	Convenient method to obtain homoallylic thioethers from aromatic dithioacetal derivatives	2019