The aim of studying and bibliography

The main aim of study: The student obtains basic knowledge of industrial microbiology and the ability to work with the bacteria for industrial use.

The general information about the module: The module is introduced in the 4th semester of the first degree studies. It is accomplished with 30 hours of lecture and 30 hours of laboratory work. It ends with an examination-based assessment.

Bibliography required to complete the module

Bibliography used during lectures

1	j. Nicklin, K. Graeme-Cook, T. Paget, R. Killington	Mikrobiologia. Krótkie wykłady.	Wydawnictwo naukowe PWN.	2000
2	Zofia Żakowska, Zdzisława Libudzisz, Krystyna Kowal	Mikrobiologia techniczna.T1 i 2.	Wydawnictwo Naukowe PWN.	2014
3	j. Nicklin, K. Graeme-Cook, T. Paget, R. Killington	Mikrobiologia. Krótkie wykłady.	Wydawnictwo naukowe PWN.	2000
4	Zofia Żakowska, Zdzisława Libudzisz, Krystyna Kowal	Mikrobiologia techniczna.T1 i 2.	Wydawnictwo Naukowe PWN.	2014

Bibliography used during classes/laboratories/others

1	H. Cieśliński, P. Filipkowski, J. Kur, A. Lass, M. Wanarska	Podstawy mikrobiologii przemysłowej. Ćwiczenia laboratoryjne.	Wydawnictwo Politechniki Gdańskiej.	2007
2	H. Cieśliński, P. Filipkowski, J. Kur, A. Lass, M. Wanarska	Podstawy mikrobiologii przemysłowej. Ćwiczenia laboratoryjne.	Wydawnictwo Politechniki Gdańskiej.	2007

Bibliography to self-study

1	Aleksander Chmiel	Biotechnologia. Podstawy mikrobiologiczne i biochemiczne	Wydawnictwo naukowe PWN.	1998
2	Aleksander Chmiel	Biotechnologia. Podstawy mikrobiologiczne i biochemiczne	Wydawnictwo naukowe PWN.	1998

Basic requirements in category knowledge/skills/social competences

Formal requirements: Passed subject: General Microbiology

Basic requirements in category knowledge: Basic knowledge of the functioning of microorganisms

Basic requirements in category skills: The ability to self-study

Basic requirements in category social competences: Ability to work both alone and in a group

Module outcomes

MEK	The student who completed the module	Types of classes / teaching methods leading to achieving a given outcome of teaching	Methods of verifying every mentioned outcome of teaching	Relationships with KEK	Relationships with PRK
01	He has knowledge of the biological and technological criteria of classification of microorganisms used in industry	lecture	written exam	K_W07+++ K_K01+++	P6S_KK P6S_KR P6S_WG
02	He knows the basic issues related to the isolation of microorganisms for industrial use from environmental samples and optimization of conditions in laboratory culture	lecture, baboratory	written exam, test	K_W07++ K_W10++	P6S_WG
03	Correctly uses the terminology in the field of taxonomy of microorganisms	lecture	written exam	K_W07++ K_K01++	P6S_KK P6S_KR P6S_WG
04	He has knowledge of secondary metabolites as precursors and specific products biosynthesis	lecture	written exam	K_W07+++	P6S_WG
05	Has knowledge related to the processes of fermentation and their implementation on an industrial scale	lecture	written exam	K_W07+++ K_W10++	P6S_WG
06	He has knowledge of the biodegradation of xenobiotics	lecture	written test	K_W07++	P6S_WG
07	He has the knowledge of the microbiology of food	lecture	written exam	K_W07+++	P6S_WG
08	He knows the basic techniques of isolation of microorganisms for industrial use from environmental samples	laboratory	written test	K_U12++	P6S_UW
09	He can perform screening of proteolytic microorganisms in the laboratory and analyze the results	laboratory	written test, student work obserwation
10	Can use basic methods for improving production characteristics of industrial microorganisms	laboratory	written test	K_W10++ K_U12++ K_U18++ K_U19+++	P6S_UO P6S_UW P6S_WG

Attention: Depending on the epidemic situation, verification of the achieved learning outcomes specified in the study program, in particular credits and examinations at the end of specific classes, can be implemented remotely (real-time meetings).

The syllabus of the module

Sem.	TK	The content	realized in	MEK
4	TK01	Biological and technological criteria for the classification of microorganisms used in the industry	W01	MEK01
4	TK02	Methods for the isolation of microorganisms for industrial use from environmental samples and optimization of conditions in laboratory culture	W02, L01, L02, L03	MEK02
4	TK03	The correct use of terminology in the field of naming microbiological	W01-W15	MEK03
4	TK04	Secondary metabolites as precursors and products of specific biosynthesis	W03, W04	MEK04
4	TK05	Fermentation processes and their implementation on an industrial scale	W05, W06, W07	MEK05
4	TK06	Mechanisms of xenobiotics biodegradation	W08, W09	MEK06
4	TK07	Microbiology of food	W10, W11, W12	MEK07
4	TK08	Techniques for isolating microorganisms for industrial use from the environmental samples	L04	MEK08
4	TK09	Screening tests of proteolytic microorganisms in a laboratory	L05	MEK09
4	TK10	Methods for improving production characteristics of industrial microorganisms	W13, W14, W15, L05	MEK10

The student's effort

The type of classes	The work before classes	The participation in classes	The work after classes
Lecture (sem. 4)	The preparation for a test: 10.00 hours/sem.	contact hours: 30.00 hours/sem.	complementing/reading through notes: 2.00 hours/sem. Studying the recommended bibliography: 15.00 hours/sem.
Laboratory (sem. 4)	The preparation for a Laboratory: 5.00 hours/sem. The preparation for a test: 5.00 hours/sem.	contact hours: 30.00 hours/sem.	Finishing/Making the report: 10.00 hours/sem.
Advice (sem. 4)	The preparation for Advice: 2.00 hours/sem.	The participation in Advice: 2.00 hours/sem.
Exam (sem. 4)	The preparation for an Exam: 15.00 hours/sem.	The written exam: 1.00 hours/sem.

The way of giving the component module grades and the final grade

The type of classes	The way of giving the final grade
Lecture	Written exam
Laboratory	written test
The final grade	50% of the exam (lecture) + 50% of the evaluation of the written test (laboratories)

Sample problems

Required during the exam/when receiving the credit
(-)

Realized during classes/laboratories/projects
(-)

Others
(-)

Can a student use any teaching aids during the exam/when receiving the credit : no

The contents of the module are associated with the research profile: yes

1	M. Misiorek; N. Pieńkowska; M. Siorek; Ż. Szymaszek; M. Twardowska; Ł. Uram; S. Wołowiec	Repurposed Drugs Celecoxib and Fmoc-L-Leucine Alone and in Combination as Temozolomide-Resistant Antiglioma Agents—Comparative Studies on Normal and Immortalized Cell Lines, and on C. elegans	2024
2	K. Balawender; K. Bulanda; K. Kroczek; B. Lewandowski; M. Oleksy; S. Orkisz; M. Potoczek; J. Szczygielski; Ł. Uram	Polylactide-based composites with hydroxyapatite used in rapid prototyping technology with potential for medical applications	2023
3	Ż. Szymaszek; M. Twardowska; Ł. Uram; M. Walczak; S. Wołowiec; K. Wróbel	Exploring the Potential of Lapatinib, Fulvestrant, and Paclitaxel Conjugated with Glycidylated PAMAM G4 Dendrimers for Cancer and Parasite Treatment	2023
4	J. Markowicz; W. Rode; Ł. Uram; S. Wołowiec	Synthesis and Properties of α-Mangostin and Vadimezan Conjugates with Glucoheptoamidated and Biotinylated 3rd Generation Poly(amidoamine) Dendrimer, and Conjugation Effect on Their Anticancer and Anti-Nematode Activities	2022
5	J. Markowicz; Ł. Uram; E. Wałajtys-Rode; S. Wołowiec; K. Wróbel	Synthesis of Biotinylated PAMAM G3 Dendrimers Substituted with R-Glycidol and Celecoxib/Simvastatin as Repurposed Drugs and Evaluation of Their Increased Additive Cytotoxicity for Cancer Cell Lines	2022
6	J. Markowicz; W. Rode; Ł. Uram; S. Wołowiec	Biotin Transport-Targeting Polysaccharide-Modified PAMAM G3 Dendrimer as System Delivering α-Mangostin into Cancer Cells and C. elegans Worms	2021
7	M. Dąbrowska; M. Dąbrowski; E. Sikora; Ł. Uram	Antigen presentation capability and AP-1 activation accompany methotrexate-induced colon cancer cell senescence in the context of aberrant β-catenin signaling	2021
8	M. Malinga-Drozd; Ł. Uram; S. Wołowiec; K. Wróbel	Chiral Recognition of Homochiral Poly (amidoamine) Dendrimers Substituted with R- and S-Glycidol by Keratinocyte (HaCaT) and Squamous Carcinoma (SCC-15) Cells In Vitro	2021
9	A. Filipowicz-Rachwał; J. Markowicz; M. Misiorek; Ł. Uram; E. Wałajtys-Rode; S. Wołowiec	Celecoxib substituted biotinylated poly(amidoamine) G3 dendrimer as potential treatment for temozolomide resistant glioma therapy and anti-nematode agent	2020
10	B. Botta; A. Calcaterra; Y. Cau; P. Maj; J. Markowicz; M. Mori; D. Quaglio ; W. Rode; J. Sobich; Ł. Uram; Z. Zieliński	Alvaxanthone, a Thymidylate Synthase Inhibitor with Nematocidal and Tumoricidal Activities	2020
11	B. Król; P. Król; K. Pielichowska; M. Sochacka-Piętal; Ł. Uram; M. Walczak	Synthesis and property of polyurethane elastomer for biomedical applications based on nonaromatic isocyanates, polyesters, and ethylene glycol	2020
12	E. Chmiel; A. Czerniecka-Kubicka; M. Misiorek; M. Pyda; P. Tutka; Ł. Uram; M. Walczak; S. Wołowiec	Stepwise glucoheptoamidation of poly(amidoamine) dendrimer G3 to tune physicochemical properties of the potential drug carrier: in vitro tests for cytisine conjugates	2020
13	J. Czarnik-Kwaśniak; I. Filiks; K. Kwaśniak; M. Stompor; K. Tutaj; Ł. Uram; S. Wołowiec	Glucoheptoamidated polyamidoamine PAMAM G3 dendrimer as a vehicle for succinate linked doxorubicin; enhanced toxicity of DOX against grade IV glioblastoma U-118 MG cells	2020
14	A. Filipowicz-Rachwał; J. Markowicz; M. Misiorek; M. Pichla; Ł. Uram; E. Wałajtys-Rode; S. Wołowiec	The Effect of Biotinylated PAMAM G3 Dendrimers Conjugated with COX-2 Inhibitor (celecoxib) and PPARγ Agonist (Fmoc-L-Leucine) on Human Normal Fibroblasts, Immortalized Keratinocytes and Glioma Cells in Vitro	2019
15	A. Filipowicz-Rachwał; M. Misiorek; Ł. Uram; E. Wałajtys-Rode; A. Winiarz; S. Wołowiec	Synthesis and Different Effects of Biotinylated PAMAM G3 Dendrimer Substituted with Nimesulide in Human Normal Fibroblasts and Squamous Carcinoma Cells	2019
16	A. Filipowicz-Rachwał; M. Szuster; Ł. Uram; E. Wałajtys-Rode; S. Wołowiec	Evaluation of the localization and biological effects of PAMAM G3 dendrimer-biotin/pyridoxal conjugate as HaCaT keratinocyte targeted nanocarrier	2019
17	D. Aebisher; A. Białońska; M. Kopaczyńska; P. Sareło; Ł. Uram; M. Walczak; S. Wołowiec; M. Zaręba	Mixed-Generation PAMAM G3-G0 Megamer as a Drug Delivery System for Nimesulide: Antitumor Activity of the Conjugate Against Human Squamous Carcinoma and Glioblastoma Cells	2019
18	M. Dąbrowska; W. Rode; M. Skoneczny; Ł. Uram	Methotrexate-induced senescence of human colon cancer cells depends on p53 acetylation, but not genomic aberrarions	2019
19	P. Maj; L. Mangiardi; J. Markowicz; W. Rode; J. Sobich; Ł. Uram	Antitumor and anti-nematode activities of α-mangostin	2019