The aim of studying and bibliography

The main aim of study: The purpose of the course is the introduction of the subject of the most important products of plant secondary metabolism and their relevance to the pharmaceutical and biotechnology industries.

The general information about the module: The module is implemented in the second semester and includes 15 hours of lectures and 15 hours of laboratory exercises. It ends with a final test. Lectures are conducted in the form of Powerpoint and Prezi presentations.

Bibliography required to complete the module

Bibliography used during lectures

1	S. Kohlmünzer	Farmakognozja. Podręcznik dla studentów farmacji	PZWL, Warszawa.	2000
2	I. Matławska,	Farmakognozja. Podręcznik dla studentów farmacji	Wydawnictwo AM w Poznaniu, Poznań.	2005
3	Z. Kowalewski	Farmakognozja. Leki roślinne,	Wydawnictwo AM w Poznaniu, Poznań, .	1997
4	A. Kołodziejczyk	Naturalne związki organiczne	PWN, Warszawa.	2003

Bibliography used during classes/laboratories/others

1	K. Dzierzbicka, D. Witt	Chemia organicznych zwiazków naturalnych	Wydawnictwo PG, Gdańsk.	2000
2	H. Strzelecka, J. Kamińska, J. Kowalski, E. Walewska	Chemiczne metody badań roślinnych surowców leczniczych	PZWL, Warszawa.	1982

Bibliography to self-study

1

E. Lamer-Zarawska, B. Kowal-Gierczak, J. Niedworok

Fitoterapia i leki roślinne

PZWL, Warszawa.

2007

Basic requirements in category knowledge/skills/social competences

Formal requirements: registration for the second semester

Basic requirements in category knowledge: Knowledge of organic and analytical chemistry is required

Basic requirements in category skills: Practical and manual skills necessary for executing laboratory experiments. Theu use of basic laboratory equipment with the valid principles of BHP and PPOŻ

Basic requirements in category social competences: Ability to cooperate in a group

Module outcomes

MEK	The student who completed the module	Types of classes / teaching methods leading to achieving a given outcome of teaching	Methods of verifying every mentioned outcome of teaching	Relationships with KEK	Relationships with PRK
01	has a basic knowledge of the physicochemical properties of discussed groups of biologically active compounds	lecture	final test	K_W03++	P7S_WG
02	knows analytical methods used for the isolation and purification of biologically active compounds from plant material	lecture	colloquium	K_W08+++	P7S_WG
03	is able to perform a qualitative and quantitative assessment of the plant material including chemical, physical, chromatographic and spectral methods	laboratory	colloquium, oral presentation	K_U08+++ K_U11++	P7S_UO P7S_UW
04	Has the ability to work individual and team while solving analytical problems	laboratory	observation of execution	K_K02+++ K_K03+++	P7S_KR

Attention: Depending on the epidemic situation, verification of the achieved learning outcomes specified in the study program, in particular credits and examinations at the end of specific classes, can be implemented remotely (real-time meetings).

The syllabus of the module

Sem.	TK	The content	realized in	MEK
2	TK01	Preliminary issues: concepts - medicinal vegetative raw material, the factors affecting the quality (collection, cultivation, drying, storage), standardization (pharmacopoeial and manufacturing standards), chemical components and biologically active compounds. Definition of secondary metabolites of plants. Chemical / biotechnological methods for their isolation, identification and purification. Characteristics of selected secondary metabolites, ie: - Glycosides (flavonoid, anthocyanin, steroids, cardiac, coumarin) - Alkaloids (purine, indole, pyridine, tropane, quinoline, isoquinoline, nicotine, Pyrrolizidine, pyrrolidine, piperidine, etc.), - Terpenes (mono-, sesqui-, di-, tri-, tetra- and polyterpenes), - phytotoxins, phytoalexin, and antibiotics of plant origin. Practical use of compounds belonging to the plant secondary metabolites	W15	MEK01 MEK02 MEK03
2	TK02	Identification and isolation of caffeine from plant materials.	L01 lub L02	MEK01 MEK02 MEK03 MEK04
2	TK03	Preparation and identification of flavonoids from the selected plant material.	L01 lub L02	MEK01 MEK02 MEK03 MEK04
2	TK04	The study of raw tannins and determination of tannins content using of Krug and Małek method.	L03	MEK01 MEK02 MEK03 MEK04

The student's effort

The type of classes	The work before classes	The participation in classes	The work after classes
Lecture (sem. 2)		contact hours: 15.00 hours/sem.	complementing/reading through notes: 2.00 hours/sem. Studying the recommended bibliography: 5.00 hours/sem.
Laboratory (sem. 2)	The preparation for a Laboratory: 3.00 hours/sem. The preparation for a test: 3.00 hours/sem.	contact hours: 15.00 hours/sem.	Finishing/Making the report: 3.00 hours/sem.
Advice (sem. 2)	The preparation for Advice: 1.00 hours/sem.	The participation in Advice: 1.00 hours/sem.
Credit (sem. 2)	The preparation for a Credit: 8.00 hours/sem.	The written credit: 1.00 hours/sem.

The way of giving the component module grades and the final grade

The type of classes	The way of giving the final grade
Lecture	A positive evaluation of the final test - OW. The note of the lecture depends on the number of obtained points from test: 3,0 (51,0 %-60,9%); 3,5 (61,0%-70,9%); 4,0 (71,0%-80,9%); 4,5 (81,0%-90,9%); 5,0 (91,0%-100%).
Laboratory	The realization of all practical exercises, preparation of the reports and obtainment of positive notes from colloquium in the range of the indicated material - OL. The note depends on the number of obtained points from test: 3,0 (51,0 %-60,9%); 3,5 (61,0%-70,9%); 4,0 (71,0%-80,9%); 4,5 (81,0%-90,9%); 5,0 (91,0%-100%).
The final grade	Final evaluation of the module is calculated by the following formula: OK = w*70%OW + w*30% OL First term: w=1, second term: w=0,9, third term: w=0,8. The final note is rounded according to the rules given in the Paper Faculty Quality of Education

Sample problems

Required during the exam/when receiving the credit
(-)

Realized during classes/laboratories/projects
(-)

Others
(-)

Can a student use any teaching aids during the exam/when receiving the credit : no

The contents of the module are associated with the research profile: yes

1	M. Kosińska-Pezda; U. Maciołek; L. Zapała	Synthesis, Spectral Characterization and Potential Fluorescent Properties of Three Lanthanide(III) Ions Complexes with Nalidixic Acid	2023
2	Ł. Byczyński; M. Kosińska-Pezda; E. Woźnicka; L. Zapała; W. Zapała	Synteza oraz badania składu i właściwości związków: 3-hydroksyflawonu, chryzyny oraz sulfonowych pochodnych chryzyny i kwercetyny z jonami Mn(II)	2023
3	Ł. Byczyński; M. Kosińska-Pezda; U. Maciołek; L. Zapała	Study of the thermal behavior, evolved gas analysis and temperature diffraction patterns of new light lanthanide complexes with niflumic acid	2023
4	E. Ciszkowicz; M. Kosińska-Pezda; K. Lecka-Szlachta; A. Miłoś; E. Woźnicka; L. Zapała	Analiza właściwości antybakteryjnych oraz cytotoksyczności kompleksów jonów Co(II), Mn(II) oraz Zn(II) z chryzyną oraz 3-hydroksyflawonem	2022
5	L. Zapała; W. Zapała; P. Ziobrowski	Studies on the retention behavior of quercetin, phenol and caffeine as test substances on selected neutral and charged Hydrophilic Interaction Liquid Chromatography stationary phases	2022
6	M. Drewniak; M. Kosińska-Pezda; U. Maciołek; A. Nowicka; L. Zapała	Synteza i charakterystyka spektroskopowa kompleksu kwasu nalidyksowego z jonami samaru(III)	2022
7	M. Kosińska-Pezda; E. Woźnicka; L. Zapała	Synteza i charakterystyka spektroskopowa kompleksów jonów lantanowców ciężkich z 3-hydroksyflawonem	2022
8	M. Kosińska-Pezda; U. Maciołek; E. Woźnicka; L. Zapała	Kompleksy 3-hydroksyflawonu z jonami Zn(II) - synteza i właściwości związków	2022
9	M. Kosińska-Pezda; U. Maciołek; E. Woźnicka; L. Zapała; W. Zapała	Synteza, badania składu i właściwości spektroskopowych kompleksów wybranych jonów metali przejściowych z kwasem niflumowym	2022
10	E. Ciszkowicz; M. Kosińska-Pezda; A. Kuźniar; K. Lecka-Szlachta; E. Pieniążek; E. Woźnicka; L. Zapała	Synteza, charakterystyka i właściwości biologiczne kompleksów jonów antanowców lekkich z 3-hydroksyflawonem	2021
11	J. Kalembkiewicz; M. Kosińska-Pezda; J. Pusz; E. Woźnicka; L. Zapała	Badania równowagi reakcji kompleksowania chryzyny z jonami Er(III) w układach: woda - metanol i woda - metanol - 1,4-dioksan	2021
12	M. Chutkowski; L. Zapała; W. Zapała; P. Ziobrowski	Analiza mechanizmu retencji kwercetyny w wybranych układach chromatografii oddziaływań hydrofilowych (HILIC)	2021
13	M. Chutkowski; M. Kosińska-Pezda; M. Przywara; L. Zapała; W. Zapała; P. Ziobrowski	Analysis of adsorption energy distribution in selected hydrophilic-interaction chromatography systems with amide, amine, and zwitterionic stationary phases	2021
14	Ł. Byczyński; E. Ciszkowicz; M. Kosińska-Pezda; K. Lecka-Szlachta; U. Maciołek; E. Woźnicka; L. Zapała; W. Zapała	Green synthesis of niflumic acid complexes with some transition metal ions (Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II)). Spectroscopic, thermoanalytical and antibacterial studies	2021
15	Ł. Byczyński; M. Kosińska-Pezda; U. Maciołek; E. Woźnicka; L. Zapała; W. Zapała	Thermal study, temperature diffraction patterns and evolved gas analysis during pyrolysis and oxidative decomposition of novel ternary complexes of light lanthanides with mefenamic acid and 1,10-phenanthroline	2021
16	J. Kalembkiewicz; B. Papciak; E. Pieniążek; J. Pusz; P. Skitał; E. Sočo; L. Zapała	Podstawy chemii	2020
17	M. Chutkowski; L. Zapała; W. Zapała; P. Ziobrowski	Influence of Mobile Phase Composition and Temperature on the Retention Behavior of Selected Test Substances in Diol-type Column	2020
18	M. Kosińska-Pezda; E. Pieniążek; E. Woźnicka; L. Zapała	Badania stałych produktów reakcji jonów Ag(I) i Cu(II) z 3-hydroksyflawonem i moryną	2020
19	M. Kosińska; E. Woźnicka; L. Zapała; W. Zapała	Response of the DFT study to the calculations of selected microdissociation constants of anthranilic acid and its derivatives	2019
20	Ł. Byczyński; M. Chutkowski; E. Ciszkowicz; M. Kosińska; K. Lecka-Szlachta; E. Woźnicka; L. Zapała; W. Zapała	Comparison of spectral and thermal properties and antibacterial activity of new binary and ternary complexes of Sm(III), Eu(III) and Gd (III) ions with N-phenylanthranilic acid and 1,10-phenanthroline	2019