The aim of studying and bibliography

The main aim of study: Introduction to the basic knowledge in the field of chemical compounds action in particular ecosystems and the environment. Familiarization with mathematical methods of risk evaluation of chemical compounds.

The general information about the module: The module is introduced in the 2nd semester of the second degree course as a mandatory module for the speciality. It is accomplished with 15 hours of lectures and 15 hours of laboratory work.

Teaching materials: http://www.nrl.uvm.sk/prz/ - stona internetowa dla studentów PRz Katedry Biochemii i Biotechnologii

Bibliography required to complete the module

Bibliography used during lectures

1	Zakrzewski Z.	Environmental toxicology, third edition	Oxford Univeristy Press.	2002
2	Legáth J.	Úvod do všeobecnej toxikológie	Study materials, UVL.	2003
3	Majerník M., Badida M., Legáth J.	Systémy environmrntálnrho manažérstva	Vienala Košice.	2002
4		Directive on the approximation of laws, regulations and administrative provisions relating to the cl	Directive 67/548/EEC.

Bibliography used during classes/laboratories/others

1

J. Legáth

Ćwiczenia – Toksykologia środoviska

http://www.nrl.uvlf.sk/prz/cwts.html.

2013

Basic requirements in category knowledge/skills/social competences

Formal requirements: Positively finished courses: General and Inorganic Chemistry, Organic Chemistry, Biochemistry and Toxicology

Basic requirements in category knowledge: Basic knowledge of inorganic and organic chemistry, biochemistry and toxicology.

Basic requirements in category skills: Self-education and searching for information skills.

Basic requirements in category social competences: Individual and team work skills.

Module outcomes

MEK	The student who completed the module	Types of classes / teaching methods leading to achieving a given outcome of teaching	Methods of verifying every mentioned outcome of teaching	Relationships with KEK	Relationships with PRK
01	Knows the basic terms and definitions and basic legislation in the field of environmental toxiology.	lecture	written test
02	Knows the problems of environmental pollution.	lecture	written test
03	Knows basic methods of risk assesment of chemical compounds in the environment and can perform risk assesment for various ecosystems and organisms	lecture	written test	K_U11++	P7S_UW
04	Knows pronciples of classification and labelling of toxic chemical compounds.	lecture, laboaratory work	written test
05	Understands the need to provide information to the public about the advantages and disadvantages of activities related to the production and application of biotechnological products and is able to convey such information in a manner commonly understood by taking into account different points of view	lecture, laboratory work	written test	K_K04+++	P7S_KO

Attention: Depending on the epidemic situation, verification of the achieved learning outcomes specified in the study program, in particular credits and examinations at the end of specific classes, can be implemented remotely (real-time meetings).

The syllabus of the module

Sem.	TK	The content	realized in	MEK
2	TK01	Introduction on the environmental toxicology, definitions, parts of ET	W01	MEK01 MEK02
2	TK02	UN Conference on Environment and Development (Rio de Janeiro, 1992)	W02	MEK01
2	TK03	Directive 67/548/EEC - Directive on the approximation of laws, regulations and administrative provisions relating to the classification, packaging and labelling of dangerous substances	W03	MEK01 MEK04 MEK05
2	TK04	Overview of basic relations in the toxicology	W04	MEK01
2	TK05	Metabolism of xenobiotcs in the organism	W05	MEK01
2	TK06	Biochemical damages and carcinogenity, teratogenity and mutagenity	W06	MEK01 MEK02
2	TK07	Introduction to problems of pollution of environment	W07	MEK02
2	TK08	Air pollution and pollution of atmosphere	W08	MEK02
2	TK09	Water pollution and soil pollution	W09	MEK02
2	TK10	Behaviour of chemical compounds in the environment (degradation and biotransformation, accumulation, persistention)	W10	MEK01 MEK02
2	TK11	Risk assessment - basic methods for characteristic risk of chemical compounds	W11	MEK03
2	TK12	Evaluation of risk of chemical compounds for aquatic and soil organisms	W12	MEK03
2	TK13	Evaluation of risk of chemical compounds for terrestrial organism and birds	W13	MEK03
2	TK14	Management of risk of chemical compounds (labelling, R-phrases, S-phrases, packing, transport …)	W14	MEK03 MEK05
2	TK15	Control methods of air, water, soil and environmental polluting	W15	MEK02
2	TK16	Risk assessment of chemical compounds – practice demonstration	L01	MEK03
2	TK17	Calculation and evaluation risk for soil organisms	L02	MEK03
2	TK18	Calculation and evaluation risk for aquatic organisms	L03	MEK03
2	TK19	Calculation and evaluation risk for birds	L04	MEK03
2	TK20	Proposals for classification and labelling of chem. compounds	L05	MEK04 MEK05
2	TK21	Summary of EU and Poland laws about environmental toxicology	L06	MEK01 MEK05

The student's effort

The type of classes	The work before classes	The participation in classes	The work after classes
Lecture (sem. 2)		contact hours: 15.00 hours/sem.	complementing/reading through notes: 4.00 hours/sem.
Laboratory (sem. 2)	The preparation for a Laboratory: 2.00 hours/sem. The preparation for a test: 6.00 hours/sem.	contact hours: 15.00 hours/sem.
Advice (sem. 2)		The participation in Advice: 2.00 hours/sem.
Credit (sem. 2)	The preparation for a Credit: 12.00 hours/sem.	The written credit: 1.00 hours/sem.

The way of giving the component module grades and the final grade

The type of classes	The way of giving the final grade
Lecture	test, examination
Laboratory	test, examination
The final grade	The final note (OK) is calculated from written test including issues from lectures and laboratory exercises. 100 points; 51-60p. - 3.0; 61-70p. - 3.5; 71-80p. - 4.0; 81-90p. - 4.5; 91-100p. - 5.0

Sample problems

Required during the exam/when receiving the credit
(-)

Realized during classes/laboratories/projects
(-)

Others
(-)

Can a student use any teaching aids during the exam/when receiving the credit : no

The contents of the module are associated with the research profile: yes

1	A. Bocian; J. Buczkowicz; K. Hus; J. Legath; T. Litschka-Koen; V. Petrilla; M. Petrillova; M. Pietrowska	Venom diversity in Naja mossambica: Insights from proteomic and immunochemical analyses reveal intraspecific differences	2024
2	B. Bakera; M. Rakoczy-Trojanowska; M. Szeliga; M. Święcicka; M. Tyrka	Identification of candidate genes responsible for chasmogamy in wheat	2023
3	P. Bednarek; A. Dorczyk; T. Drzazga; D. Jasińska; P. Krajewski; B. Ługowska; R. Martofel; P. Matysik; M. Niewińska; D. Ratajczak; K. Rączka; T. Sikora; D. Tyrka; M. Tyrka; E. Witkowski; U. Woźna-Pawlak	Genome-wide association mapping in elite winter wheat breeding for yield improvement	2023
4	A. Bocian; J. Gikunju; K. Hus; J. Kimotho ; J. Legath; E. Manson; K. Mutinda; V. Petrilla	Development of an Inhibition Enzyme-Linked Immunosorbent Assay (ELISA) Prototype for Detecting Cytotoxic Three-Finger Toxins (3FTxs) in African Spitting Cobra Venoms	2022
5	A. Bocian; K. Hus; J. Kimani; J. Kimotho ; M. Kyama; J. Legath; E. Manson; V. Petrilla	Development and Characterization of Anti-Naja ashei Three-Finger Toxins (3FTxs)-Specific Monoclonal Antibodies and Evaluation of Their In Vitro Inhibition Activity	2022
6	M. Dyda; G. Gołębiowska; M. Rapacz; M. Szechyńska-Hebda; M. Tyrka; I. Wąsek; M. Wędzony	Quantitative trait loci and candidate genes associated with freezing tolerance of winter triticale (× Triticosecale Wittmack)	2022
7	M. Dyda; G. Gołębiowska; M. Rapacz; M. Tyrka; M. Wędzony	Genetic mapping of adult-plant resistance genes to powdery mildew in triticale	2022
8	M. Dyda; G. Gołębiowska; M. Rapacz; M. Tyrka; M. Wędzony	Mapping of QTL and candidate genes associated with powdery mildew resistance in triticale (× Triticosecale Wittm.)	2022
9	P. Krajewski; R. Marcinkowski; R. Martofel; P. Matysik; M. Mokrzycka; M. Rakoczy-Trojanowska; M. Rokicki; S. Stojałowski; M. Tyrka; U. Woźna-Pawlak; B. Żmijewska	Genome-Wide Association Analysis for Hybrid Breeding in Wheat	2022
10	A. Barbasz; A. Bocian; A. Czyżowska; B. Dyba; K. Hus; J. Legath; V. Petrilla; M. Petrillova; E. Rudolphi-Szydło	Effects of 3FTx Protein Fraction from Naja ashei Venom on the Model and Native Membranes: Recognition and Implications for the Mechanisms of Toxicity	2021
11	A. Pietrusińska; M. Tyrka	Linkage of Lr55 wheat leaf rust resistance gene with microsatellite and DArT-based markers	2021
12	B. Bakera; P. Krajewski; M. Mokrzycka; M. Rakoczy-Trojanowska; M. Szeliga; M. Święcicka; M. Tyrka	Identification of Rf Genes in Hexaploid Wheat (Triticumaestivum L.) by RNA-Seq and Paralog Analyses	2021
13	B. Bakera; P. Krajewski; P. Matysik; M. Mokrzycka; M. Rakoczy-Trojanowska; M. Rokicki; S. Stojałowski; M. Szeliga; D. Tyrka; M. Tyrka	Evaluation of genetic structure in European wheat cultivars and advanced breeding lines using high-density genotyping-by-sequencing approach	2021
14	J. Buczkowicz; T. Drzazga; B. Ługowska; P. Matysik; K. Rubrycki; M. Semik; D. Tyrka; M. Tyrka; E. Witkowski	Identyfikacja efektywnych genów odporności na wybrane choroby wirusowe i grzybowe pszenicy zwyczajnej	2021
15	J. Buczkowicz; T. Drzazga; G. Fic; M. Jaromin; P. Krajewski; P. Matysik; R. Mazur; P. Milczarski; T. Sikora; M. Szeliga; D. Tyrka; M. Tyrka; E. Witkowski	Selekcja genomowa pszenicy ozimej	2021
16	A. Bocian; J. Buczkowicz; E. Ciszkowicz; K. Hus; K. Lecka-Szlachta; J. Legath; L. Legath; V. Petrilla; M. Petrillova; M. Pietrowska	Antimicrobial Activity of Protein Fraction from Naja ashei Venom Against Staphylococcus epidermidis	2020
17	A. Bocian; J. Buczkowicz; K. Hus; M. Jaromin; J. Legath; D. Łysiak; V. Petrilla; M. Petrillova; S. Sławek	Comparison of Methods for Measuring Protein Concentration in Venom Samples	2020
18	A. Bocian; K. Hus; E. Kuna; J. Legath; A. Lewińska; V. Petrilla; M. Petrillova; M. Wnuk	Evaluation of Antifungal Activity of Naja pallida and Naja mossambica Venoms against Three Candida Species	2020
19	A. Bocian; K. Hus; J. Legath; Ł. Marczak; V. Petrilla; M. Petrillova	Different research approaches in unraveling the venom proteome of Naja ashei	2020
20	E. Ciszkowicz; E. Kaznowska; P. Porzycki; M. Semik; M. Tyrka	MiR-93/miR-375: Diagnostic Potential, Aggressiveness Correlation and Common Target Genes in Prostate Cancer	2020
21	G. Czajowski; M. Karbarz; M. Pojmaj; A. Strzembicka; D. Tyrka; M. Tyrka; A. Wardyńska; M. Wędzony	Quantitative trait loci mapping of adult-plant resistance to powdery mildew in triticale	2020
22	J. Ciura; M. Szeliga; M. Tyrka	Representational Difference Analysis of Transcripts Involved in Jervine Biosynthesis	2020
23	A. Bocian; J. Buczkowicz; K. Hus; M. Jaromin; J. Legath	An effective method of isolating honey proteins	2019
24	J. Ciura; M. Grzesik; M. Szeliga; M. Tyrka	Identification of candidate genes involved in steroidal alkaloids biosynthesis in organ-specific transcriptomes of Veratrum nigrum L.	2019
25	J. Legath; D. Marcincakova; M. Miłek	Polyphenols Content, Antioxidant Activity, and Cytotoxicity Assessment of Taraxacum officinale Extracts Prepared through the Micelle-Mediated Extraction Method	2019
26	M. Dyda; M. Szechyńska-Hebda; M. Tyrka; I. Wąsek; M. Wędzony	Local and systemic regulation of PSII efficiency in triticale infected by the hemibiotrophic pathogen Microdochium nivale	2019
27	M. Dziurka; K. Hura; T. Hura; A. Ostrowska; M. Tyrka	Participation of Wheat and Rye Genome in Drought Induced Senescence in Winter Triticale (X Triticosecale Wittm.)	2019
28	T. Csank; M. Falis; M. Fedorova; K. Hus; J. Legath; S. Marcincak; D. Marcincakova; D. Mudronova; P. Schusterova	Impact of Zinc Sulfate Exposition on Viability, Proliferation and Cell Cycle Distribution of Epithelial Kidney Cells	2019
29	Z. Banaszak; A. Fiust; Z. Nita; W. Orłowska-Job; M. Pojmaj; M. Rapacz; M. Tyrka; M. Wójcik-Jagła	Sposób selekcji mrozoodpornych genotypów jęczmienia ozimego	2019