The aim of studying and bibliography

The main aim of study: The aim of the education is to provide knowledge on the classification of biocompatible materials and the main directions of their applications. Understanding the importance of biocompatible materials in the development of modern medicine, perspectives and role in improving the quality of life, with particular emphasis on polymeric biocompatible materials.

The general information about the module: The module is realized in first semester of the studiess of second degree. It is realized during 10 hours of lectures and 30 hours of laboratory and ends by the credit.

Teaching materials: Opracowania do cwiczen laboratoryjnych (6x)

Bibliography required to complete the module

Bibliography used during lectures

1	Rabek J.	Współczesna wiedza o polimerach	PWN.	2008
2	Marciniak J.	Biomateriały	Wydawnictwo Politechniki Sląskiej.	2002
3	Rabek J.	Współczesna wiedza o polimerach, polimery naturalne i syntetyczne, otrzymywanie i zastosowanie, t.2	PWN.	2017
4	Świeczko-Żurek B.	Biomateriały	Wydawnictwo Politechniki Gdańskiej.	2009
5	Burczyk A., Bogdał D., Pielichowski J.	Polifosfazeny: synteza, właściwości, nowe kierunki zastosowania	Przemysł Chemiczny, 48(10), 1370-1375.	2003
6	Achremowicz B., Korus J.	Właściwości, produkcja i zastosowanie cyklodekstryn	Żywność. Technologia. Jakość, 3(8), 14-27.	1996
7	Cieślak-Golonka, M., Starosta, J., Wasielewski, M.	Wstęp do chemii koordynacyjnej	PWN.	2013
8	Dodziuk H.	Wstęp do chemii supramolekularnej	WUW.	2008
9	Sznitowska M.	Farmacja stosowana technologia postaci leku	PZWL.	2017
10	Kołodziejczyk A.	Naturalne związki organiczne	PWN.	2013
11	Oleszko-Torbus N., Utrata-Wesołek A, Wałach W., Dworak A., Trzebicka B.	Nowe termowrażliwe powierzchnie polimerowe do hodowli i uwalniania komórek skóry	Wiadomości chemiczne, 70(11-12), 803-818.	2016
12	Utrata-Wesołek A., Trzebicka B., Dworak A.	Polimery wrażliwe na bodźce	Polimery, 53(10), 717-724.	2008
13	Ukielski R., Sobiecki P.	Inteligentne polimery z termicznym efektem pamięci	Polimery, 53(11-12), 793-804.	2008
14	Pielichowski J., Pruszyński A.	Chemia polimerów	wyd. Teza, Kraków.	2004
15	Olaru N. , Olaru L., Vasile C., Ander P.	Surface modified cellulose obtained by acetylation without solvents of bleached and unbleached kraft pulps	Polimery, 56(11-12), 834-840.	2011
16	Qiu X., Hu S.	”Smart” Materials Based on Cellulose: A Review of the Preparations, Properties, and Applications	Materials, 6, 738-781.	2013

Bibliography used during classes/laboratories/others

1	J. Gawroński, K. Gawrońska, K. Kacprzak, M. Kwit	Współczesna synteza organiczna, wybór eksperymentów	PWN.	2012
2	J.F. Rabek	Współczesna wiedza o polimerach	Wydawnictwo PWN.	2008
3	D. Stewart, C. D. Gutsche	Isolation, Characterization, and Conformational Characteristics of p-tert-Butylcalix[9−20]arenes	J. Am. Chem. Soc., 121(17), 4136–4146.	1999
4	A. Vogel	Preparatyka organiczna	WNT.	2006
5	P. Kowalski	Laboratorium chemii organicznej	WNT.	2004
6	Z. Wang, I. Cedillo, D. L. Cole, Y. S. Sanghvi, M. Hinz, W. Prukała, M. Sobkowski, H. Seliger, M. Rimmler, R. Ditz, J. Hoffmeyer	A New PVA Support for Oligonucleotide Synthesis at Large Scale. Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries	Mayflower Worldwide Ltd, Birmigham, 118-122.	2004
7	Z. Florjańczyk, S. Penczek	Chemia polimerów, t.1, Makrocząsteczki i metody icotrzymywania	OWPW.	2001
8	Z. Florjańczyk, S. Penczek	Chemia polimerów, t.2, Podstawowe polimery syntetyczne i ich zastosowanie	OWPW.	2001

Basic requirements in category knowledge/skills/social competences

Formal requirements: Registration for the first semester.

Basic requirements in category knowledge: Basic knowledge of inorganic, organic and polymer chemistry.

Basic requirements in category skills: The ability of the selfstudy. Ability to present structural formulas and write organic reactions.

Basic requirements in category social competences: The ability both the independent work as and the team.

Module outcomes

MEK	The student who completed the module	Types of classes / teaching methods leading to achieving a given outcome of teaching	Methods of verifying every mentioned outcome of teaching	Relationships with KEK	Relationships with PRK
01	Student has the basic knowledge on the subject of biocompatible materials used in medicine and pharmacy.	lecture, laboratory	credit of written part, written report.	K_W08++	P7S_WG
02	Student knows classification and the use of biocompatible materials and the methods of their analysis.	lecture, laboratory	written test, written report	K_W05++ K_W07++	P7S_WG
03	Student can work in a team in the synthesis of polymeric materials.	laboratory	credit of practical part, credit of written part	K_U08+++ K_U11+++	P7S_UO P7S_UW
04	Student understands of additional education for professional improve, in particuliarity for application of in biocompatible material, in medicine, pharmacy and stomatology.	lecture	written test	K_K01+++	P7S_KK

Attention: Depending on the epidemic situation, verification of the achieved learning outcomes specified in the study program, in particular credits and examinations at the end of specific classes, can be implemented remotely (real-time meetings).

The syllabus of the module

Sem.	TK	The content	realized in	MEK
1	TK01	The introduction: the Classification of biocompatible materials. Division, chemical and supermolecule structures. The review important biocompatible, polymeric, ceramic, and metallic materials.	W01	MEK01
1	TK02	Natural biocompatible polymer materials - cellulose, chitosan, cyclodextrins, hyaluronic acid	W02	MEK01
1	TK03	Synthetic biocompatible oligo- and polymers - calixarenes, vinyl polymers	W03	MEK02
1	TK04	Inorganic-organic polymers - polyphosphazenes, polysiloxanes	W04	MEK02
1	TK05	Smart polymers Amphiphilic polymers	W05	MEK02 MEK04
1	TK06	Preparation of macrocyclic compounds - p-tert-butylkalix[6]arene	L01, L02, L03	MEK03
1	TK07	Vinyl acetate polymerization (VAC) to polyvinyl acetate (PVAC)	L04	MEK03
1	TK08	Hydrolysis of polyvinyl acetate PVAC to polyvinyl alcohol (PVA)	L05	MEK03 MEK04
1	TK09	Crosslinking of poly (vinyl alcohol) PVA with the use of boron compounds	L06	MEK03

The student's effort

The type of classes	The work before classes	The participation in classes	The work after classes
Lecture (sem. 1)		contact hours: 10.00 hours/sem.	complementing/reading through notes: 2.00 hours/sem. Studying the recommended bibliography: 4.00 hours/sem.
Laboratory (sem. 1)	The preparation for a Laboratory: 4.00 hours/sem. The preparation for a test: 4.00 hours/sem.	contact hours: 30.00 hours/sem.	Finishing/Making the report: 8.00 hours/sem.
Advice (sem. 1)	The preparation for Advice: 2.00 hours/sem.	The participation in Advice: 2.00 hours/sem.
Credit (sem. 1)	The preparation for a Credit: 8.00 hours/sem.	The written credit: 1.00 hours/sem.

The way of giving the component module grades and the final grade

The type of classes	The way of giving the final grade
Lecture	The final score is exposed in the adequate way to the number of points got on the colloquium: very good from 92.1% to 100% good plus from 82.1% to 92.0% good from 72.1% to 82.0% sufficient plusfrom 72.1% to 82.0% sufficient from 52.1% to 62.0% insufficient less than 52.00.
Laboratory	The arithmetic mean of the grades obtained from individual exercises on the basis of a short test of preparation for the exercise, conducting of the exercise and a written report. ery good from 4.71 good plus from 4.26 to 4.70 good from 3.76 to 4.25 sufficient plus from 3.31 to 3.75 sufficient from 2.76 to 3 30 insufficient less than 2.76.
The final grade	50% score from the colloquium (E) + 50% final score from laboratories(L): Final Assessment (K): K = 0.5wL + 0.5W (where w = 1, the first term; w = 0.9 second term, w = 0.8 third term) very good from 4.71 good plus from 4.26 to 4.70 good from 3.76 to 4.25 sufficient plus from 3.31 to 3.75 sufficient from 2.76 to 3 30 insufficient less than 2.76.

Sample problems

Required during the exam/when receiving the credit
(-)

Realized during classes/laboratories/projects
(-)

Others
(-)

Can a student use any teaching aids during the exam/when receiving the credit : no

The contents of the module are associated with the research profile: yes

1	A. Czerniecka-Kubicka; L. Dobrowolski; K. Hęclik; I. Zarzyka	Kompozyt polimerowy oraz sposób wytwarzania kompozytu polimerowego	2024
2	M. Bakar; A. Białkowska; B. Hanulikova; W. Kucharczyk; M. Masař; I. Zarzyka	Polylactide-Based Nonisocyanate Polyurethanes: Preparation, Properties Evaluation and Structure Analysis	2024
3	A. Czerniecka-Kubicka; A. Szyszkowska; I. Zarzyka	Hybrydowy nanokompozyt polimerowy i sposób jego otrzymywania	2023
4	A. Czerniecka-Kubicka; B. Krzykowska; I. Zarzyka	Bionanocomposites based on the poly(3-hydroxybutyrate) matrix modified with aliphatic polyurethanes and nanoclay	2023
5	A. Czerniecka-Kubicka; G. Neilsen; M. Pyda; M. Skotnicki; P. Tutka; B. Woodfield; I. Zarzyka	Heat capacity of cytisine – the drug for smoking cessation	2023
6	A. Czerniecka-Kubicka; M. Pyda; M. Skotnicki; I. Zarzyka	Liquid heat capacity of amorphous poly(vinyl methyl ether)	2023
7	A. Czerniecka-Kubicka; W. Gonciarz; B. Jadach; M. Kovářová; L. Lovecká; K. Maternia-Dudzik; M. Pyda; V. Sedlařík; M. Skotnicki; P. Tutka; I. Zarzyka	The cytisine-enriched poly(3-hydroxybutyrate) fibers for sustained-release dosage form	2023
8	A. Szyszkowska; I. Zarzyka	Sposób wytwarzania estru	2023
9	L. Dobrowolski; K. Hęclik; M. Jaromin; I. Zarzyka	A Practical Test of Distance Learning During the COVID-19 Lockdown	2023
10	M. Bakar; A. Białkowska; A. Czerniecka-Kubicka; L. Dobrowolski; K. Hęclik; B. Krzykowska; M. Longosz; I. Zarzyka	Polymer Biocompositions and Nanobiocomposites Based on P3HB with Polyurethane and Montmorillonite	2023
11	M. Bakar; A. Białkowska; A. Czerniecka-Kubicka; M. Kovářová; B. Krzykowska; V. Sedlařík; I. Zarzyka	Polymer/Layered Clay/Polyurethane Nanocomposites: P3HB Hybrid Nanobiocomposites—Preparation and Properties Evaluation	2023
12	M. Bakar; A. Białkowska; W. Kucharczyk; I. Zarzyka	Hybrid Epoxy Nanocomposites: Improvement in Mechanical Properties and Toughening Mechanisms—A Review	2023
13	M. Chmiela; A. Czerniecka-Kubicka; L. Dobrowolski; W. Gonciarz; K. Hęclik; M. Longosz; A. Szyszkowska; D. Trzybiński; K. Woźniak; A. Wróbel; I. Zarzyka	Molecular Modeling of 3-chloro-3-phenylquinoline-2,4-dione, Crystal Structure and Cytotoxic Activity for developments in a potential new drug	2023
14	M. Bakar; A. Białkowska; A. Czerniecka-Kubicka; L. Dobrowolski; K. Hęclik; B. Krzykowska; I. Zarzyka	Biobased poly(3-hydroxybutyrate acid) composites with addition of aliphatic polyurethane based on polypropylene glycols	2022
15	A. Czerniecka-Kubicka; M. Pyda; I. Zarzyka	Sposób pomiaru ciepła właściwego alifatycznego poliuretanu liniowego, zwłaszcza 4,6-PU	2021
16	K. Hęclik; K. Hęclik; I. Zarzyka	Metal-Humus Acid Nanoparticles - Synthesis, Characterization and Molecular Modeling	2021
17	M. Bakar; A. Białkowska; A. Czerniecka-Kubicka; L. Dobrowolski; K. Hęclik; K. Leś; M. Pyda; M. Walczak; I. Zarzyka	Thermally stable biopolymer composites based on poly(3-hydroxybutyrate) modified with linear aliphatic polyurethanes – preparation and properties	2021
18	W. Frącz; T. Pacześniak; I. Zarzyka	Rigid polyurethane foams modified with borate and oxamide groups-Preparation and properties	2021
19	A. Białkowska; L. Dobrowolski; L. Wianowski; I. Zarzyka	Physical blowing agents for polyurethanes	2020
20	A. Czerniecka-Kubicka; L. Dobrowolski; K. Hęclik; I. Zarzyka	Biodegradowalne kompozyty polimerowe na osnowie P3HB	2020
21	A. Czerniecka-Kubicka; M. Dickson; D. Hojan-Jezierska; M. Janus-Kubiak; L. Kubisz; G. Neilsen; M. Pyda; M. Skotnicki; B. Woodfield; I. Zarzyka; W. Zielecki	Vibrational heat capacity of silver carp collagen	2020
22	A. Czerniecka-Kubicka; M. Pyda; I. Zarzyka	Long-Term Physical Aging Tracked by Advanced Thermal Analysis of Poly(N-Isopropylacrylamide): A Smart Polymer for Drug Delivery System	2020
23	A. Szyszkowska; I. Zarzyka	Sposób wytwarzania 1-fenylo-2-(2-hydroksyetylo)-6H-imidazo[1,5-c]chinazolino-3,5-dionu i 1-fenylo-2-(2-hydroksypropylo)-6H-imidazo[1,5-c]chinazolino-3,5-dionu	2020
24	M. Bakar; A. Białkowska; B. Hanulikova; M. Masař; I. Zarzyka	Effect of structure of nonisocyanate condensation polyurethanes based on benzoic acid on its susceptibility to biodegradation	2020
25	R. Bartosik; L. Dobrowolski; K. Hęclik; A. Klasek; A. Lycka; I. Zarzyka	New mono- and diesters with imidazoquinolinone ring- synthesis, structure characterization and molecular modeling	2020
26	Ł. Byczyński; A. Czerniecka-Kubicka; W. Frącz; M. Pyda; V. Sedlarik; A. Szyszkowska; I. Zarzyka	Hybrid nanobiocomposites based on poly(3-hydroxybutyrate) – characterization, thermal and mechanical properties	2020
27	A. Czerniecka-Kubicka; A. Szyszkowska; I. Zarzyka	Hybrydowy nanokompozyt polimerowy i sposób jego otrzymywania	2019
28	A. Szyszkowska; I. Zarzyka	Sposób otrzymywania 1,3-bis(2-hydroksyetylo)-4-fenylo-5-[2(2-oksoksazol-3-ylo)fenylo]imidazol-2-onu	2019
29	J. Lubczak; R. Lubczak; I. Zarzyka	Sposób otrzymywania polieteroli z pierścieniami azacyklicznymi	2019
30	K. Hęclik; A. Klasek; S. Pawlędzio; A. Szyszkowska; D. Trzybiński; K. Woźniak; I. Zarzyka	Unprecedented reaction course of 1-phenyl-2H,6H-imidazo[1,5-c]quinazoline-3,5-dione with an excess of ethylene oxide	2019
31	K. Hęclik; A. Szyszkowska; I. Zarzyka	Spatial packing of diols and esters with imidazoquinazoline ring - quantum-mechanical modelling	2019
32	Ł. Byczyński; A. Czerniecka-Kubicka; K. Gancarczyk; M. Pyda; V. Sedlarik; A. Szyszkowska; I. Zarzyka	Linear polyurethanes with imidazoquinazoline rings: preparation and properties evaluation	2019