The aim of studying and bibliography

The main aim of study: The goalof the course is to familarize students with the work of bioreactors, their application, mathematical description of biochemical reactions and designing bioreactors.

The general information about the module: Student obtains knowledge in the scope of stoichiometry of microbial growth, kinetics of microbial growth, product formation, kinetics of enzymatic reaction, modeling and application of bioreactors.

Bibliography required to complete the module

Bibliography used during lectures

1	B. Tabiś, R. Grzywacz	Procesy i reaktory biochemiczne	Politechnika Krakowska.	1993
2	K.W. Szewczyk	Technologia biochemiczna	OW Politechniki Warszawskiej.	1995
3	S. Aiba, A.E. Humphrey, N.F. Millis	Inżynieria biochemiczna.	WNT.	1997
4	K.W. Szewczyk	Bilansowanie i kinetyka procesów biochemicznych	OW Politechniki Warszawskiej.	2000

Bibliography used during classes/laboratories/others

1	Bałdyga J., M. Henczka, W. Podgórska	Obliczenia w inżynierii bioreaktorów	OW Politechniki Warszawskiej.	1996
2	Garcia-Fruitos Elena	Insoluble proteins	Methods in Molecular Biology, Springer Protocols.	2015

Bibliography to self-study

1

M. Shuler, F Kargi

Bioprocess Engineering

Prentice-Hall.

2001

Basic requirements in category knowledge/skills/social competences

Formal requirements: Registration for semester VI in the field of Pharmaceutical Engineering

Basic requirements in category knowledge: BBasic knowledge of bioprocess engineering, mathematics, physical chemistry and cell biology

Basic requirements in category skills: Student is able to formulate material balance equations for simple processes and has basic knowledge of stoichiometry and reaction kinetics.

Basic requirements in category social competences: Student is able to work in a team

Module outcomes

MEK	The student who completed the module	Types of classes / teaching methods leading to achieving a given outcome of teaching	Methods of verifying every mentioned outcome of teaching	Relationships with KEK	Relationships with PRK
01	the student has knowledge of stoichiometry, kinetics, energy effects of biochemical reactions and the design of bioreactors, knows the basic types of bioreactors used in industry, can desing bioreactor	lecture, laboratory	test, realization of task	K_W04+ K_W05+ K_U08+ K_U09+ K_U11+ K_K01+ K_K02+	P6S_KK P6S_KO P6S_KR P6S_UW P6S_WG
02	The student has knowledge of the basic microorganisms used in biochemical processes, knows examples of bioreactors in industry.	lecture	writting test	K_W04+ K_W05+ K_K01+	P6S_KK P6S_WG
03	The student has knowledge in the field of control and control of the microbial culture process in a bioreactor in order to obtain a bio-product.	laboratory	colloquium, written report	K_W05+ K_U11+ K_K01+ K_K02+	P6S_KK P6S_KO P6S_KR P6S_UW P6S_WG

Attention: Depending on the epidemic situation, verification of the achieved learning outcomes specified in the study program, in particular credits and examinations at the end of specific classes, can be implemented remotely (real-time meetings).

The syllabus of the module

Sem.	TK	The content	realized in	MEK
6	TK01	811 / 5 000 Wyniki tłumaczenia Tłumaczenie Basic microorganisms used in biochemical processes and their properties. Stoichiometry of biochemical reactions. Kinetics of biochemical reactions. Models of microbial population kinetics: kinetics of substrate and product consumption, kinetics of cell growth, kinetics of enzymatic reactions, kinetics taking into account the age and physiological heterogeneity of the population. Modeling the work of biochemical reactors. Batch reactor, single tank reactor, single tank reactor, tank reactor cascade, plug flow tubular reactor. Types of bioreactors used in industry, apparatus solutions. Examples of using bioreactors in the pharmaceutical and biopharmaceutical industries. Issues related to modeling mass transfer processes in bioreactors and transferring the scale of the process	wykład 20 h , lab 20h	MEK01 MEK02
6	TK02	Production of recombinant proteins or antibiotics in various cellular systems. Purification of insoluble proteins.	Lab1-20	MEK03

The student's effort

The type of classes	The work before classes	The participation in classes	The work after classes
Lecture (sem. 6)	The preparation for a test: 4.00 hours/sem.	contact hours: 20.00 hours/sem.	complementing/reading through notes: 1.00 hours/sem. Studying the recommended bibliography: 2.00 hours/sem.
Laboratory (sem. 6)	The preparation for a Laboratory: 1.00 hours/sem. The preparation for a test: 3.00 hours/sem.	contact hours: 20.00 hours/sem.	Finishing/Making the report: 3.00 hours/sem.
Advice (sem. 6)
Credit (sem. 6)	The preparation for a Credit: 3.00 hours/sem.	The written credit: 2.00 hours/sem.

The way of giving the component module grades and the final grade

The type of classes	The way of giving the final grade
Lecture	On the basis of the mark obtained in test. Factor "w" taking into account the date of completion: w=1 for the first term; w=0.9 for the second term; w=0.8 for the third term.
Laboratory	Laboratory - solving selected problems by the use of MATLAB software.Factor "w" taking into account the date of completion: w=1 for the first term; w=0.9 for the second term; w=0.8 for the third term.
The final grade	he final mark (OK) is calulated as follows: OK= 0,65*OW + 0,35*OL; OW - mark for lecture, OL - mark for laboratory

Sample problems

Required during the exam/when receiving the credit
(-)

Realized during classes/laboratories/projects
(-)

Others
(-)

Can a student use any teaching aids during the exam/when receiving the credit : no

The contents of the module are associated with the research profile: no