The aim of studying and bibliography

The main aim of study: Teaching studets about methods of pharmaceutical purification

The general information about the module: The course consist of lecture 15 h and laboratory 15h. It concerns the most typical methods isolating and purification of pharmaceuticals and biopharmaceuticals by crystallization processes in industrial applications. It also concerns drying of pharmaceuticals and biopharmaceuticals.

Bibliography required to complete the module

Bibliography used during lectures

1	Z.Rojkowski, J. Synowiec	Krystalizacja i krystalizatory	WNT.	1991
2	A.Mersmann	Crystallization technology handbook	Marcel Dekker.	2001
3	R.G. Harrison, P. W. Todd, S. R. Rudge, D. P. Petrides	Bioseparations science and engineering	Oxford University Press.	2015
4	Praca zbiorowa pod redakcją doc. dr hab. Piotra P. Lewickiego	Inżynieria procesowa i aparatura przemysłu spożywczego	WNT, Warszawa.	1982
5	David Kozma	Handbook of: Optical resolutions via diastereomeric salt formation	CRC Press, New York.	2002
6	Eric Francotte, Wolfgang Lindner	Chirality in drug research	WILEY-VCH.	2006
7	Z. Kembłowski, S. Michałowski, C. Strumiłło, R. Zarzycki	Podstawy teoretyczne inżynierii chemicznej i procesowej	WNT.	1985

Bibliography used during classes/laboratories/others

1	R.G. Harrison, P. W. Todd, S. R. Rudge, D. P. Petrides	Bioseparations science and engineering	Oxford University Press.	2015
2	praca zbiorowa pod red. R Petrusa	Inżynieria Chemiczna Laboratorium	Of. Wyd. PRz..	1988
3	W. Zapała, K. Kaczmarski, I. Poplewska, W. Piątkowski	Wybrane operacje jednostkowe w inżynierii procesowej	Of. Wyd. PRz..	2012

Bibliography to self-study

1	S. Ledakowicz	Inżynieria biochemiczna	WNT.	2018
2	K. Sakai, N. Hirayama, R. Tamura	Novel optical resolution technologies	Springer, .	2005

Basic requirements in category knowledge/skills/social competences

Formal requirements: Semester registration

Basic requirements in category knowledge: Knowledge about chemical engineering esspecially about mass and heat transfer. Basic knowlege about mathematics and phisical chemistry.

Basic requirements in category skills: Basic knowlegde about chemical and process engineering, mathematics and physical chemistry. Ability to use literature and make notes. Ability to work in the laboratory.

Basic requirements in category social competences: Student is able to work in a team

Module outcomes

MEK	The student who completed the module	Types of classes / teaching methods leading to achieving a given outcome of teaching	Methods of verifying every mentioned outcome of teaching	Relationships with KEK	Relationships with PRK
01	Student gain knowledge about separation of pharmaceuticals and biopharmaceuticals by crystallization and drying them.	lecture	written test	K_W08+ K_U08+ K_U09+ K_K01+	P6S_KK P6S_UW P6S_WG
02	Student can perform crystallization process for selected pharmaceutical substances and drying process for wet solid materials. Student can handle proper apparatus.	laboratory classes	passing out of test and reports from all laboratory classes	K_W08+ K_U08+ K_U09+ K_K01+	P6S_KK P6S_UW P6S_WG

Attention: Depending on the epidemic situation, verification of the achieved learning outcomes specified in the study program, in particular credits and examinations at the end of specific classes, can be implemented remotely (real-time meetings).

The syllabus of the module

Sem.	TK	The content	realized in	MEK
6	TK01	Methods fo crystallization - process definition, crystallization equilibrium, mathematical description and graphic presentation of crystallization equilibrium, process kinetics, kinetic equations of mass transfer in crystallization. Salting out. Crystallization of biopharmaceuticals. Separation of enantiomers and diastereoisomers by crystallization process.	W01-W05; L01-L04	MEK01 MEK02
6	TK02	Drying- process definition, drying equilibrium. Drying kinetics, drying curves. First and second period of drying. Realization of drying process in industry.	W06-W07; L05	MEK01 MEK02

The student's effort

The type of classes	The work before classes	The participation in classes	The work after classes
Lecture (sem. 6)	The preparation for a test: 8.00 hours/sem.	contact hours: 15.00 hours/sem.	complementing/reading through notes: 2.00 hours/sem. Studying the recommended bibliography: 2.00 hours/sem.
Laboratory (sem. 6)	The preparation for a test: 5.00 hours/sem.	contact hours: 15.00 hours/sem.	Finishing/Making the report: 4.00 hours/sem.
Advice (sem. 6)
Credit (sem. 6)

The way of giving the component module grades and the final grade

The type of classes	The way of giving the final grade
Lecture	On the basis of the mark obtained in test. Factor "w" taking into account the date of completion: w=1 for the first term; w=0.9 for the second term; w=0.8 for the third term.
Laboratory	Based on the mark obtained in test if the all reports are accepted.Factor "w" taking into account the date of completion: w=1 for the first term; w=0.9 for the second term; w=0.8 for the third term.
The final grade	The final mark (OK) is calulated as follows: OK= 0,65*OW + 0,35*OL; OW - mark for lecture, OL - mark for laboratory

Sample problems

Required during the exam/when receiving the credit
(-)

Realized during classes/laboratories/projects
(-)

Others
(-)

Can a student use any teaching aids during the exam/when receiving the credit : no

The contents of the module are associated with the research profile: yes

1	D. Antos; M. Korbetskyy; P. Mruc; M. Olbrycht	Altering the mobile phase composition to enhance self-disproportionation of enantiomers in achiral chromatography	2024
2	D. Antos; M. Balawejder; J. Gumieniak; P. Mruc; M. Olbrycht; W. Piątkowski	Separation of non-racemic mixtures of enantiomers by achiral chromatography	2023
3	D. Antos; M. Kołodziej; W. Piątkowski; T. Rumanek	Preferential precipitation of acidic variants from monoclonal antibody pools	2023
4	D. Antos; M. Kołodziej; W. Piątkowski; T. Rumanek; P. Zimoch	Coupling of chromatography and precipitation for adjusting acidic variant content in a monoclonal antibody pool	2023
5	D. Antos; A. Bajek-Bil; M. Balawejder; M. Olbrycht; W. Piątkowski	Sposób otrzymywania stereoizomeru szczawianu nafronylu o konfiguracji absolutnej (2S, 2\'R)	2021
6	D. Antos; A. Bajek-Bil; M. Balawejder; M. Olbrycht; W. Piątkowski; I. Poplewska	Development of a Route to the Most Active Nafronyl Stereoisomer by Coupling Asymmetric Synthesis and Chiral Chromatography Separation	2021
7	D. Antos; P. Antos; M. Balawejder; R. Bochenek; J. Gorzelany; K. Kania; M. Kołodziej; N. Matłok; M. Olbrycht; W. Piątkowski; M. Przywara; G. Witek	Sposób wytwarzania nawozu wieloskładnikowego o kontrolowanym uwalnianiu składników	2021
8	D. Antos; G. Carta; M. Kołodziej; R. Muca; W. Piątkowski	Effects of negative and positive cooperative adsorption of proteins on hydrophobic interaction chromatography media	2020
9	D. Antos; J. Beck; A. Durauer; R. Hahn; A. Jungbauer; M. Kołodziej; W. Marek; W. Piątkowski; D. Sauer	Scale up of a chromatographic capture step for a clarified bacterial homogenate - Influence of mass transport limitation and competitive adsorption of impurities	2020
10	D. Antos; P. Antos; M. Balawejder; R. Bochenek; M. Kołodziej; N. Matłok; M. Olbrycht; W. Piątkowski; M. Przywara	Mechanism of nutrition activity of a microgranule fertilizer fortified with proteins	2020
11	D. Antos; M. Balawejder; H. Lorenz; M. Olbrycht; W. Piątkowski; I. Poplewska; A. Seidel-Morgenstern	Cooperative Kinetic Model to Describe Crystallization in Solid Solution Forming Systems	2019
12	D. Antos; M. Kołodziej; A. Łyskowski; W. Piątkowski; I. Poplewska; P. Szałański	Determination of protein crystallization kinetics by a through-flow small-angle X-ray scattering method	2019
13	D. Antos; P. Antos; M. Balawejder; R. Bochenek; J. Gorzelany; K. Kania; M. Kołodziej; N. Matłok; M. Olbrycht; W. Piątkowski; M. Przywara; G. Witek	Sposób wytwarzania nawozu wieloskładnikowego o kontrolowanym uwalnianiu składników	2019