The aim of studying and bibliography

The main aim of study: o familiarize students with technological operations and chemical processes used in the pharmaceutical industry during the production of final therapeutic agents, active substances and auxiliary materials.

The general information about the module: The subject is run in the fifth semester. It includes 30 hours of lecture and 30 hours of laboratory exercises.

Bibliography required to complete the module

Bibliography used during lectures

1	K. Kieć-Kononowicz (red.)	Wybrane zagadnienia z metod poszukiwania i otrzymywania środków leczniczych	Wydawnictwo Uniwersytetu Jagielońskiego.	2006
2	Red. Janicki S., Fiebig A., Sznitowska M.	Farmacja stosowana	Wydawnictwo Lekarskie PZWL.	2008
3	R. Kasprzykowska, F. Kasprzykowski	Preparatyka organiczna środków farmaceutycznych	Wydawnictwo Uniwesytetu Gdańskiego.	2018
4	L. Kuczyński	Technologia leków	WNT.	1971
5	K. Dzierzbicka, D. Witt	Chemia leków syntetycznych	Wydawnictwo Politechniki Gdańskiej.	2019
6	Red. W. Bednarski, J. Fiedurka	Podstawy biotechnologii przemysłowej	WNT.	2007
7	T. Tkaczyński, D. Tkaczyńska	Synteza i technologia chemiczna leków	PZWL.	1984

Bibliography used during classes/laboratories/others

1	Red. Janicki S., Fiebig A., Sznitowska M.	Farmacja stosowana	Wydawnictwo Lekarskie.	2008
2	R. Kasprzykowska, F. Kasprzykowski	Preparatyka organiczna środków farmaceutycznych	Wydawnictwo Uniwrsytetu Gdańskiego.	2018

Basic requirements in category knowledge/skills/social competences

Formal requirements: Registration for the fifth semester.

Basic requirements in category knowledge: Basic knowledge of physical chemistry, inorganic and organic, and the methods of analysis.

Basic requirements in category skills: Ability to apply basic laboratory techniques.

Basic requirements in category social competences: Awareness of the need to work in teams of 2-3 people

Module outcomes

MEK	The student who completed the module	Types of classes / teaching methods leading to achieving a given outcome of teaching	Methods of verifying every mentioned outcome of teaching	Relationships with KEK	Relationships with PRK
01	He knows the basic physical operations chemical processes used in the manufacture of various groups of pharmaceuticals.	lecture, laboratory	written test, observation of performance, written report	K_W02+ K_W06+++ K_U05+	P6S_UW P6S_WG
02	He knows the physical and chemical properties of selected medicinal substances	lecture, laboratory	written test, observation of performance, written report	K_W07+	P6S_WG
03	A student is able to perform experiments (syntheses, analyses), draws the correct conclusions and prepares the final reports based on the obtained results and scientific literature.	laboratory	written test, observation of performance, written report	K_U06+ K_K02+	P6S_KO P6S_KR P6S_UW

Attention: Depending on the epidemic situation, verification of the achieved learning outcomes specified in the study program, in particular credits and examinations at the end of specific classes, can be implemented remotely (real-time meetings).

The syllabus of the module

Sem.	TK	The content	realized in	MEK
5	TK01	Introduction. Principles classification of drugs, drug origins, factors affecting drug action, side effects of drugs.	W01-02	MEK01
5	TK02	-	W03-W10	MEK01 MEK01
5	TK03	-	W11-W16	MEK01
5	TK04	Production of the selected therapeutic agents including the following pharmacological groups: analgesic and antipyretic, anti-inflammatory agents, local anesthetics, sedatives and hypnotics and analgesics, psychotropic drugs, agents and sympathicotonic, antihypertensive agents, and diuretics, anticoagulants, agents with antidiabetic agents, antihistamines	W17-W25	MEK01
5	TK05	The technology of manufacturing the selected hormones, alkaloids, glycosides, and vitamins.	W26-W30
5	TK06	Preparation of selected pharmaceutical substances and auxiliary materials in a laboratory scale.	L01-L06	MEK02 MEK03

The student's effort

The type of classes	The work before classes	The participation in classes	The work after classes
Lecture (sem. 5)		contact hours: 30.00 hours/sem.	complementing/reading through notes: 6.00 hours/sem.
Laboratory (sem. 5)	The preparation for a Laboratory: 18.00 hours/sem. The preparation for a test: 24.00 hours/sem.	contact hours: 30.00 hours/sem.	Finishing/Making the report: 18.00 hours/sem.
Advice (sem. 5)
Exam (sem. 5)	The preparation for an Exam: 30.00 hours/sem.	The written exam: 2.00 hours/sem.

The way of giving the component module grades and the final grade

The type of classes	The way of giving the final grade
Lecture	Positive evaluation of a written test (min. 50% points). Details will be included in the examination sheet. In the case of resit, the score with a coefficient of 0.9.
Laboratory	Completion of all planned exercises, reports, as well as a written test. The final grade is the arithmetic average of the marks of the written test and reports.
The final grade	The final mark is issued on the basis of exam and laboratory grades. Final rating (K): K = 0.6E + 0.4L; where: E, L means a satisfactory grade for the exam and the laboratory

Sample problems

Required during the exam/when receiving the credit
(-)

Realized during classes/laboratories/projects
(-)

Others
(-)

Can a student use any teaching aids during the exam/when receiving the credit : no

The contents of the module are associated with the research profile: yes

1	K. Bester; A. Bukowska; W. Bukowski; A. Kawka; M. Pytel	Salophen chromium(III) complexes functionalized with pyridinium salts as catalysts for carbon dioxide cycloaddition to epoxides	2024
2	K. Bester; A. Bukowska; W. Bukowski; M. Drajewicz; K. Dychtoń; R. Ostatek; P. Szałański	Sposób wytwarzania salofenowego kompleksu chromu(III)	2024
3	K. Bester; A. Bukowska; W. Bukowski; S. Flaga	Reactive Polymer Composite Microparticles Based on Glycidyl Methacrylate and Magnetite Nanoparticles	2024
4	A. Bukowska; T. Galek; M. Przywara; R. Przywara; W. Zapała	Brief Analysis of Selected Sorption and Physicochemical Properties of Three Different Silica-Based Adsorbents	2023
5	K. Bester; A. Bukowska; W. Bukowski; M. Drajewicz; K. Dychtoń; R. Ostatek; P. Szałański	Ligand salphenowy oraz sposób syntezy tego ligandu salphenowego	2023
6	K. Bester; W. Bukowski; M. Kaczmarek; D. Tomczyk	Electrocatalytic Properties of Ni(II) Schiff Base Complex Polymer Films	2022
7	K. Bester; W. Bukowski; P. Seliger; D. Tomczyk	The Influence of Electrolyte Type on Kinetics of Redox Processes in the Polymer Films of Ni(II) Salen-Type Complexes	2022
8	K. Bester; A. Bukowska; W. Bukowski	Homogeniczny katalizator chromowy, sposób jego wytwarzania, układ katalityczny zawierający ten katalizator oraz zastosowanie tego układu katalitycznego	2021
9	K. Bester; A. Bukowska; W. Bukowski; M. Pytel	Polymer Beads Decorated with Dendritic Systems as Supports for A3 Coupling Catalysts	2021
10	K. Bester; A. Bukowska; W. Bukowski; M. Pytel; A. Sobota	Copolymerization of Phthalic Anhydride with Epoxides Catalyzed by Amine-Bis(Phenolate) Chromium(III) Complexes	2021
11	A. Bukowska; A. Drelinkiewicz; D. Duraczyńska; L. Lityńska-Dobrzyńska; E. Serwicka; R. Socha; M. Zimowska	Solvent and substituent effects in hydrogenation of aromatic ketones over Ru/polymer catalyst under very mild conditions	2019
12	K. Bester; A. Bukowska; W. Bukowski	Homogeniczny katalizator chromowy, sposób jego wytwarzania, układ katalityczny zawierający ten katalizator oraz zatosowanie tego układu katalitycznego	2019
13	K. Bester; W. Bukowski; D. Tomczyk	Kinetics of Redox Processes in the Polymer Films of Ni(II) Salen Type Complexes	2019