The aim of studying and bibliography

The main aim of study: Acquiring basic information about the functioning of organs and systems. Understanding the basic laws governing the body in health and how to adapt to changing external and internal conditions.

The general information about the module: Classes include 15 hours lecture and end with a written test.

Bibliography required to complete the module

Bibliography used during lectures

1	Władysław Z. Traczyk	Fizjologia człowieka w zarysie	PZWL, wydanie VIII.	2020
2	Michajlik, A., Ramotowski, W.	Anatomia i fizjologia człowieka	Warszawa: PZWL.	2013
3	Tafil-Klawe, M., Klawe, J. J. (red.)	Wykłady z fizjologii człowieka	Warszawa: PZWL. .	2017
4	McLaughlin, D., Stamford, J., White, D.	Fizjologia człowieka	Warszawa: PWN.	2012

Bibliography to self-study

1	Tomasz Brzozowski	Fizjologia człowieka Konturek	Edra Urban & Partner wyd. III.	2019
2	Górski, J. (red.)	Fizjologia człowieka	Warszawa: PZWL.	2010

Basic requirements in category knowledge/skills/social competences

Formal requirements: registration for first semester

Basic requirements in category knowledge: Basics of biology

Basic requirements in category skills:

Basic requirements in category social competences:

Module outcomes

MEK	The student who completed the module	Types of classes / teaching methods leading to achieving a given outcome of teaching	Methods of verifying every mentioned outcome of teaching	Relationships with KEK	Relationships with PRK
01	knows the physiology of nervous systems, endocrine, circulatory, lymphatic, reproductive, digestive, urinary and respiratory systems; adaptive mechanisms of nervous, hormonal and thermoregulatory regulation	lecture	written test	K_W02++ K_K01+	P6S_KK P6S_WG
02	knows and understands the mechanisms of modification of physiological processes by pharmacological agents	lecture	written test	K_W02++ K_K01+	P6S_KK P6S_WG
03	describes the mechanisms of the functioning of the human body at all levels of its organization, considers the individual functions of the human body as related elements of the integrated whole, characterizes the adaptation possibilities of the organism	lecture	written test	K_W02++ K_K01+	P6S_KK P6S_WG
04	uses the acquired knowledge to analyze the functional state of the body in order to optimize and individualize pharmacotherapy and prophylaxis	lecture	written test	K_W02++ K_K01+	P6S_KK P6S_WG

Attention: Depending on the epidemic situation, verification of the achieved learning outcomes specified in the study program, in particular credits and examinations at the end of specific classes, can be implemented remotely (real-time meetings).

The syllabus of the module

Sem.	TK	The content	realized in	MEK
1	TK01	Functions of the cell membrane and intracellular elements. Neurons. Synaptic conduction. Fundamentals of electrophysiology. Skeletal and smooth muscle physiology. Spinal cord - reflexes. The motor axis, functions of the cerebellum, basal ganglia, reticular formation of the spinal core. Spinal shock. Feeling and perception. The role of the thalamus. Sensory organs. Centers in the cerebral cortex. Conditional reflexes. The hypothalamus and the autonomic nervous system. Functions of the limbic system. Internal environment control - endocrine system. Blood function (plasma composition and functions, red cell system). Blood activity (white blood cells, blood clotting). Heart function - action potentials, contractions, stimulus-conductive system. The hemodynamic cycle of the heart. EKG. The circulatory system - functions, flow, pressure, heart rate. The vasomotor and cardiac center. Circulation regulation. Respiratory system. Urinary tract.	W01-W15	MEK01 MEK02 MEK03 MEK04

The student's effort

The type of classes	The work before classes	The participation in classes	The work after classes
Lecture (sem. 1)		contact hours: 15.00 hours/sem.	Studying the recommended bibliography: 3.00 hours/sem.
Advice (sem. 1)
Credit (sem. 1)	The preparation for a Credit: 10.00 hours/sem.	The written credit: 2.00 hours/sem.

The way of giving the component module grades and the final grade

The type of classes	The way of giving the final grade
Lecture	written test in the form of a single-choice test
The final grade	The written test mark depends on the score gained: satisfactory (50%- 59%), fairly good (60%-69%), good (70%-79%); more than good (80%-89%) very good when student achieve more than 90% of the maximum score.

Sample problems

Required during the exam/when receiving the credit
(-)

Realized during classes/laboratories/projects
(-)

Others
(-)

Can a student use any teaching aids during the exam/when receiving the credit : no

The contents of the module are associated with the research profile: yes

1	M. Misiorek; N. Pieńkowska; M. Siorek; Ż. Szymaszek; M. Twardowska; Ł. Uram; S. Wołowiec	Repurposed Drugs Celecoxib and Fmoc-L-Leucine Alone and in Combination as Temozolomide-Resistant Antiglioma Agents—Comparative Studies on Normal and Immortalized Cell Lines, and on C. elegans	2024
2	K. Balawender; K. Bulanda; K. Kroczek; B. Lewandowski; M. Oleksy; S. Orkisz; M. Potoczek; J. Szczygielski; Ł. Uram	Polylactide-based composites with hydroxyapatite used in rapid prototyping technology with potential for medical applications	2023
3	Ż. Szymaszek; M. Twardowska; Ł. Uram; M. Walczak; S. Wołowiec; K. Wróbel	Exploring the Potential of Lapatinib, Fulvestrant, and Paclitaxel Conjugated with Glycidylated PAMAM G4 Dendrimers for Cancer and Parasite Treatment	2023
4	J. Markowicz; W. Rode; Ł. Uram; S. Wołowiec	Synthesis and Properties of α-Mangostin and Vadimezan Conjugates with Glucoheptoamidated and Biotinylated 3rd Generation Poly(amidoamine) Dendrimer, and Conjugation Effect on Their Anticancer and Anti-Nematode Activities	2022
5	J. Markowicz; Ł. Uram; E. Wałajtys-Rode; S. Wołowiec; K. Wróbel	Synthesis of Biotinylated PAMAM G3 Dendrimers Substituted with R-Glycidol and Celecoxib/Simvastatin as Repurposed Drugs and Evaluation of Their Increased Additive Cytotoxicity for Cancer Cell Lines	2022
6	J. Markowicz; W. Rode; Ł. Uram; S. Wołowiec	Biotin Transport-Targeting Polysaccharide-Modified PAMAM G3 Dendrimer as System Delivering α-Mangostin into Cancer Cells and C. elegans Worms	2021
7	M. Dąbrowska; M. Dąbrowski; E. Sikora; Ł. Uram	Antigen presentation capability and AP-1 activation accompany methotrexate-induced colon cancer cell senescence in the context of aberrant β-catenin signaling	2021
8	M. Malinga-Drozd; Ł. Uram; S. Wołowiec; K. Wróbel	Chiral Recognition of Homochiral Poly (amidoamine) Dendrimers Substituted with R- and S-Glycidol by Keratinocyte (HaCaT) and Squamous Carcinoma (SCC-15) Cells In Vitro	2021
9	A. Filipowicz-Rachwał; J. Markowicz; M. Misiorek; Ł. Uram; E. Wałajtys-Rode; S. Wołowiec	Celecoxib substituted biotinylated poly(amidoamine) G3 dendrimer as potential treatment for temozolomide resistant glioma therapy and anti-nematode agent	2020
10	B. Botta; A. Calcaterra; Y. Cau; P. Maj; J. Markowicz; M. Mori; D. Quaglio ; W. Rode; J. Sobich; Ł. Uram; Z. Zieliński	Alvaxanthone, a Thymidylate Synthase Inhibitor with Nematocidal and Tumoricidal Activities	2020
11	B. Król; P. Król; K. Pielichowska; M. Sochacka-Piętal; Ł. Uram; M. Walczak	Synthesis and property of polyurethane elastomer for biomedical applications based on nonaromatic isocyanates, polyesters, and ethylene glycol	2020
12	E. Chmiel; A. Czerniecka-Kubicka; M. Misiorek; M. Pyda; P. Tutka; Ł. Uram; M. Walczak; S. Wołowiec	Stepwise glucoheptoamidation of poly(amidoamine) dendrimer G3 to tune physicochemical properties of the potential drug carrier: in vitro tests for cytisine conjugates	2020
13	J. Czarnik-Kwaśniak; I. Filiks; K. Kwaśniak; M. Stompor; K. Tutaj; Ł. Uram; S. Wołowiec	Glucoheptoamidated polyamidoamine PAMAM G3 dendrimer as a vehicle for succinate linked doxorubicin; enhanced toxicity of DOX against grade IV glioblastoma U-118 MG cells	2020
14	A. Filipowicz-Rachwał; J. Markowicz; M. Misiorek; M. Pichla; Ł. Uram; E. Wałajtys-Rode; S. Wołowiec	The Effect of Biotinylated PAMAM G3 Dendrimers Conjugated with COX-2 Inhibitor (celecoxib) and PPARγ Agonist (Fmoc-L-Leucine) on Human Normal Fibroblasts, Immortalized Keratinocytes and Glioma Cells in Vitro	2019
15	A. Filipowicz-Rachwał; M. Misiorek; Ł. Uram; E. Wałajtys-Rode; A. Winiarz; S. Wołowiec	Synthesis and Different Effects of Biotinylated PAMAM G3 Dendrimer Substituted with Nimesulide in Human Normal Fibroblasts and Squamous Carcinoma Cells	2019
16	A. Filipowicz-Rachwał; M. Szuster; Ł. Uram; E. Wałajtys-Rode; S. Wołowiec	Evaluation of the localization and biological effects of PAMAM G3 dendrimer-biotin/pyridoxal conjugate as HaCaT keratinocyte targeted nanocarrier	2019
17	D. Aebisher; A. Białońska; M. Kopaczyńska; P. Sareło; Ł. Uram; M. Walczak; S. Wołowiec; M. Zaręba	Mixed-Generation PAMAM G3-G0 Megamer as a Drug Delivery System for Nimesulide: Antitumor Activity of the Conjugate Against Human Squamous Carcinoma and Glioblastoma Cells	2019
18	M. Dąbrowska; W. Rode; M. Skoneczny; Ł. Uram	Methotrexate-induced senescence of human colon cancer cells depends on p53 acetylation, but not genomic aberrarions	2019
19	P. Maj; L. Mangiardi; J. Markowicz; W. Rode; J. Sobich; Ł. Uram	Antitumor and anti-nematode activities of α-mangostin	2019