The aim of studying and bibliography

The main aim of study: Acquainting with stages of the the medicine design and methods receiving them.

The general information about the module: The lecture and the Laboratory given on 6 semester, during of 30 hr of lectures and 30 hr of the laboratory. The module is ending with the credit.

Teaching materials: Instrukcje do ćwiczeń laboratoryjnych dostępne ze strony www katedry

Bibliography required to complete the module

Bibliography used during lectures

1	Patrick L. G.,	Chemia Leków. Krótkie wykłady	PWN.	2004
2	Silverman R.B.,	Chemia Organiczna w Projektowaniu Leków	WNT, Warszawa.	2004
3	Kieć-Kononowicz K. (red)	Wybrane zagadnienia z metod poszukiwania i otrzymywania środków leczniczych.	Wydawnictwo UJ.	2006
4	Parick L. G.,	Chemia Medyczna. Podstawowe zagadnienia.	WNT.	2003

Bibliography used during classes/laboratories/others

1

Instrukcje wewnętrzne Katedry

.

Bibliography to self-study

1	Tkaczyński T., Tkaczyńska D.	Synteza i technologia chemiczna leków	PZWL, Warszawa .	1984
2	Tułecki J.	Technologia środków leczniczych.	PZWL, Warszawa.	1978
3	Binecki S.	Preparatyka środków leczniczych.	PZWL, Warszawa.	1983

Basic requirements in category knowledge/skills/social competences

Formal requirements: Registration for the given semester

Basic requirements in category knowledge: Basic knowledge in the, general chemistry, physical and analytical chemistry, and organic chemistry.

Basic requirements in category skills: Ability of choice the way of the synthesis of organic compounds, showing analysis methods.

Basic requirements in category social competences: Ability of the cooperation and the work in the group.

Module outcomes

MEK	The student who completed the module	Types of classes / teaching methods leading to achieving a given outcome of teaching	Methods of verifying every mentioned outcome of teaching	Relationships with KEK	Relationships with PRK
01	Student is able to choose and to apply basic techniques of receiving the medical product/drug.	lecture, laboratory	pass the written part, and the practical part.	K_W10++ K_W12++ K_U16++ K_U17++ K_K03+	P6S_KR P6S_UO P6S_UW P6S_WG
02	Student knows basic techniques of the quantitative analysis and quality of medical product.	lecture, laboratory	pass the written lecture material, and the practical part.	K_W10++ K_U16++ K_U17++ K_K03+	P6S_KR P6S_UO P6S_UW P6S_WG

Attention: Depending on the epidemic situation, verification of the achieved learning outcomes specified in the study program, in particular credits and examinations at the end of specific classes, can be implemented remotely (real-time meetings).

The syllabus of the module

Sem.	TK	The content	realized in	MEK
6	TK01	Drug from the idea for the implementation: Leading Structure - search; relation between the structure and the activity of the drug; Pharmacokinetics; QSAR; Combinatorial Synthesis. Laboratory: chosen methods of synthesis of drugs.	MEK01, MEK02	MEK01 MEK02
6	TK02	Definition of the medicine/drug, stages of seeking the medicine, choice of the site of action of the medicine, choice of the biological assay, seeking the leading structure.	W01,W02,W03	MEK01 MEK02
6	TK03	Synthesis on the solid phase - bases and assumptions.	W04	MEK01 MEK02
6	TK04	Combinatorial synthesis - idea, methods.	W05, W06	MEK01 MEK02
6	TK05	Isolation and purification of the active ingredient, elucidation the structure of the active compound.	W07, W08	MEK01 MEK02
6	TK06	Pharmacophore, isostere - definition, examples.	W09, W10	MEK01 MEK02
6	TK07	Synthesis of the most populardrugs e.g. prazole, antibiotics, betablockers and statins.	W11, W12	MEK01 MEK02
6	TK08	Elements of strategy of planning the synthesis of new potential drugs. The most popular types of the reaction used in the synthesis of medicines/drugs in including analysis of the applied synthesis in the pharmaceutical industry.	W13, W14	MEK01 MEK02
6	TK09	Written passing the subject.	W15	MEK01 MEK02
6	TK10	Performing five laboratory exercises from the area of the isolation, the synthesis and analysis of medical products during of 5 lesson according to instructions placed on sd of the coordinator, before beginning of the cycle classes.	L01-L06	MEK01 MEK02

The student's effort

The type of classes	The work before classes	The participation in classes	The work after classes
Lecture (sem. 6)		contact hours: 18.00 hours/sem.	complementing/reading through notes: 10.00 hours/sem. Studying the recommended bibliography: 10.00 hours/sem. Others: 15.00 hours/sem.
Laboratory (sem. 6)	The preparation for a Laboratory: 10.00 hours/sem. The preparation for a test: 15.00 hours/sem.	contact hours: 18.00 hours/sem.	Finishing/Making the report: 10.00 hours/sem.
Advice (sem. 6)
Credit (sem. 6)	The preparation for a Credit: 20.00 hours/sem.	The written credit: 2.00 hours/sem.

The way of giving the component module grades and the final grade

The type of classes	The way of giving the final grade
Lecture	Written credit of lecture material. The student is obtaining 15 questions from material of lecture scored 0,0-1.0 pt/every question - generally 15 pt of the 100%). Evaluations: 60-67 % evaluation 3.0; 68-75 % evaluation 3.5; 76-83 % evaluation 4.0; 84-91 % evaluation 4.5; 92-100 % evaluation 5.0.
Laboratory	Evaluation from the laboratory (OL): arithmetic mean from carrying each of five exercises out, understanding an operation and processes of everyone of exercising, the written report of every practical session.
The final grade	Final evaluation (K): K = 0.4 wL + 0.6 wZ: where L and from is denoting the positive assessment appropriately from the laboratory and the lecture, w-współczynnik date taking into account of ranking, w = 1.0 the first term, w = 0.9 the second term, w = 0.8 the third term.

Sample problems

Required during the exam/when receiving the credit
(-)

Realized during classes/laboratories/projects
(-)

Others
(-)

Can a student use any teaching aids during the exam/when receiving the credit : no

The contents of the module are associated with the research profile: no