The aim of studying and bibliography

The main aim of study: The challenge for bioengineering is made the most ofpossibities upturn in the life quality, the economi, social, and technological developmen, enviromental protection. This challenge is the essence of the balanced development. In particular student should to learn the designing of processes and products, technological processes, which are economical, innovatory, energy-saving. Moreovwer student should to to achieve one’s goal in standards of safety in production, to deliver humankind the future processess and products.

The general information about the module: The module is implemented on the fifth and sixth semester. In sem. 5 the module includes 30 hours.L, 15 hours. Exc.; 15 hours. L.;In sem. 6 the module includes 15 hours L.,15 hours. Ex. Semester 5 ends with a credit. Semester 6 ends with an exam. Lecture panel-assisted exercises where shown the practical applications of theory to examples of task, and in addition to the laboratory, where they are shown the practical means of experimental studies on the processes of chemical engineering processes and the interpretation of experimental data. Student the Bioengibeering basic knowlegde - in first heat and mass trasfer theory. The next he learns how he should to apply these theories to unit Bioengibeering processes. Student gets to knowtegde about mechanismes of the unit processes, mathematical modelling methods and opymization.

Bibliography required to complete the module

Bibliography used during lectures

1	T. Hobler	Ruch ciepła i wymienniki	WNT W-wa.	1986
2	T. Hobler	Dyfuzyjny ruch masy i absorbery	WNT W-wa.	1976
3	M. Serwiński	Zasady inżynierii chemicznej i procesowej	WNT W-wa.	1982
4	Praca zbior. pod red. Z Ziółkowskiego	Procesy dyfuzyjne i termodynamiczne , cz. I; II; III	skrypt Pol. Wrocławskiej .	1980
5	D. Antos, K.Kaczmarski, W. Piątkowski	Wymiana ciepła	Mat. Pom. Of. Wyd. PRz.	2012
6	Cz. Strumiłło	Podstawy teorii i techniki suszenia	WNT W-wa.	1983
7	K. Kaczmarski , W.. Piątkowski	Ruch masy	Mat. pom. Of . Wyd. PRz.	2014
8	D. Antos, W.. Piątkowski	Procesy dyfuzyjne	Mat. pom. Of . Wyd. PRz.	2014
9	D. Antos, W. Piątkowski	Procesy równoczesnego ruchu ciepła i masy	Mat. pom. Of . Wyd. PRz.	2014

Bibliography used during classes/laboratories/others

1	W. Zapała, K. Kaczmarski, I.. Poplewska, W. Piątkowski	Wybrane operacje jednostkowe w inżynierii chemicznej - laboratorium	Of. Wyd. PRz..	1990
2	R. Zarzycki	Zadania rachunkowe z Inżynierii Chemicznej	PWN Łódź.	1980
3	Praca zbiorowa pod red. J. Bandrowskiego i M. palicy	Materiały pomocnicze do ćwiczeń i projektów z Inzynierii chemicznej	Wyd. Pol. Śl..	2005
4	Z. Kawala; MM. Pająk; J. Szust 13 T. Kudra	Zbiór zadań z podstawowych procesów Inżynierii Chemicznej	skrypt Pol. Wrocławskiej cz.: II oraz III .	1979
5	K.F.Pawłow; P.G. Romankow; A.A. Noskow	Przykłady i zadania z zakresu aparatury i inżynierii chemicznej	.
6	T. Kudra (pod redakcją)	Zbiór zadań z podstaw teoretycznych inżynierii chemicznej i procesowej	WNT W-wa.	1985
7	praca zbiorowa pod red. PRz	Inżynieria Chemiczna Laboratorium	Of. Wyd. PRz.	1998

Bibliography to self-study

1	Z. Ziółkowski	Ekstrakcja w przemyśle chemicznym	WNT W-wa.	1980
2	St. Bredsznajder	Własności gazów i cieczy	WNT W-wa.	1962
3	Z. Rojkowski, J. Synowiec	Krystalizacja i krystalizatory	.
4	R. Petrus, G. Aksielrud, J. Gumnicki, W. Piątkowski	Wymiana masy w układzie ciecz-ciało stałe	Of. Wyd. PRz.	1998

Basic requirements in category knowledge/skills/social competences

Formal requirements: Registration for the semester.s V and VI of field of study: Biootechnology according to study programme at Chemistry Faculty of RUT.

Basic requirements in category knowledge: Knowlegde on applied mathematics, physical chemistry, chemical thermodynamics

Basic requirements in category skills: 1. Basic konwledge in the area of: phsysics, mathematics, phsysical chemistry, informatics, 2. Ability to learn from textbooks, lecture notes, to make out lecture notes. 3. Ability to solve proble

Basic requirements in category social competences: Ability to intellectual work in the group

Module outcomes

MEK	The student who completed the module	Types of classes / teaching methods leading to achieving a given outcome of teaching	Methods of verifying every mentioned outcome of teaching	Relationships with KEK	Relationships with PRK
01	The student gains knowledge of the theoretical basis of Bioprocess Engineering. Based on the theory of basic processes, ie. heat transfer, mass transfer taught describe the basic processes of separation of mixtures, including biological mixtures.	problem lecture, table exercises; problem exercises; problem lab.	the exam: written and oral part, colloquium 2times/sem.	K_W10++ K_W18++ K_U12+ K_K01+	P6S_KK P6S_KR P6S_UW P6S_WG
02	Student based on the basic theories of processes, ie. heat transfer, mass transfer taught describe the basic processes of separation of mixtures, including biological mixtures.	problem lecture; table exercises; problem lab	Exam: written and oral part, colloquium 2 times/sem.	K_W10+ K_W18+ K_U12+ K_K01+	P6S_KK P6S_KR P6S_UW P6S_WG

Attention: Depending on the epidemic situation, verification of the achieved learning outcomes specified in the study program, in particular credits and examinations at the end of specific classes, can be implemented remotely (real-time meetings).

The syllabus of the module

Sem.	TK	The content	realized in	MEK
5	TK01	Heat Transfer: (Fixed) Stationary Heat Transfer, Heat Transfer Driving Force, Kinds of the Heat Transfer: Thermal Conduction, I-St Fourier Law, Thermal Conduction Coefficient, Heat Non- And Conductors, Thermal Conduction Across Wall, Heat Transfer Resistance, Heat Convection – Newton Equation, Heat Transfer Cases, Criterial Numbers And Equations, Heat Radiation, Heat Screen Meaning, Heat Losses to Environment, Overall Heat Transfer, Newton Equation for Overall Heat Transfer, Overall Heat Transfer Coefficient, Some Cases of Transient Heat Transfer, Basis Of Heat Exchanger Design. Mass Transfer: (Fixed) Stationary Mass Transfer, Driving Force, Mass Diffusion, I-St Fick Law, Mass Diffusion Coefficients, Mass Transfer Resistance, Kinds of the Mass Diffusion, Mass Diffusion, Mass Convection, Newton Kinetic Equation, Mass Transfer Cases, Criterial Numbers And Equations, Overall Mass Transfer, Newton Equation for Overall Mass Transfer, Overall Mass Transfer Coefficient, Disappearance of Mass Transfer Resistance, Overall Mass Transfer Driving Force, Basis Of Mass Exchanger Design. Concurrent Heat and Mass Transfer – Basic Knowledge Absorption; A) Process Definition, B) Static’s of the Process – Absorption Equilibrium, Kinds of the Equilibrium Line Notations, C) Process Kinetics, Mass and Overall Mass Transport in the Absorption, D) Mass Balance of the Absorption, Operation Line of the Absorption, Minimum of the Spraying Liquid Mass and Velocity, E) Overall Mass Transfer Driving Force int Absorption, F) Dynamic Model of the Absorption,Chemisorption.	-	MEK01 MEK02
6	TK01	Distillation And Rectification: Points A) to F) Analogous to the Same Above with the Following Differences: Distillation Equilibrium for Binary Component System, Kinds of the Equilibrium Line Notations - for Ideal System – Raoult Law, Nonideal Systems – Aberrations From Raoult Law, Azeotropes, Differential Distillation, Equilibrium Distillation, Mass and Overall Mass Transport in the Rectification, Batch Rectification, Continuous Rectification, Heat and Mass Balances of the Rectification, Heat and Mass Balances of the Operated Plate, Operation Lines of the Rectification, Minimum and Maximum Minimum of the Column Reflux, Column Efficiency Measured by Theoretical Plate Amount. Exstraction: Points A) to F) Analogous to the Same Above with the Following Differences: Extraction Equilibrium for Ternary Component System, Ideal System – Nernst Law, Nonideal Systems – Aberrations From Nernst Law, Stepping Extraction Parallel-Current and Counter-Current Extraction, Minimum and Maximum of the Extrahent Mass, Kinds of the Mathematics Solution of the Mentioned Above Extraction Cases, Column Extraction, Dynamic Model of the Column Extraction.	-	MEK01 MEK02

The student's effort

The type of classes	The work before classes	The participation in classes	The work after classes
Lecture (sem. 5)	The preparation for a test: 3.00 hours/sem.	contact hours: 18.00 hours/sem.	complementing/reading through notes: 5.00 hours/sem. Studying the recommended bibliography: 15.00 hours/sem.
Class (sem. 5)	The preparation for a Class: 5.00 hours/sem. The preparation for a test: 5.00 hours/sem.	contact hours: 9.00 hours/sem.	Finishing/Studying tasks: 5.00 hours/sem.
Advice (sem. 5)
Credit (sem. 5)	The preparation for a Credit: 15.00 hours/sem.	The written credit: 4.00 hours/sem. The oral credit: 1.00 hours/sem.
Lecture (sem. 6)	The preparation for a test: 5.00 hours/sem.	contact hours: 9.00 hours/sem.	complementing/reading through notes: 5.00 hours/sem. Studying the recommended bibliography: 15.00 hours/sem.
Class (sem. 6)	The preparation for a Class: 4.00 hours/sem. The preparation for a test: 2.00 hours/sem.	contact hours: 9.00 hours/sem.	Finishing/Studying tasks: 3.00 hours/sem.
Laboratory (sem. 6)		contact hours: 9.00 hours/sem.
Advice (sem. 6)	The preparation for Advice: 2.00 hours/sem.	The participation in Advice: 2.00 hours/sem.
Exam (sem. 6)	The preparation for an Exam: 8.00 hours/sem.	The written exam: 2.00 hours/sem. The oral exam: 1.00 hours/sem.

The way of giving the component module grades and the final grade

The type of classes	The way of giving the final grade
Lecture	Passing the Lecture evaluation on the result of the test.:.OW: Credit: 0-25 – 2.0 (ndst) 26-32 – 3.0 (dst) 33-38 – 3.5 (dst+) 39-43 – 4.0 (db) 44-47 – 4.5 (db+) 48-50 – 5.0 (bdb) Factor related to the term Course test OW / Credit w=1 - 1-st term; w=0.9 - 2-nd term; w=0.8 - 3rd term. w=0.8 - 3-rd term;
Class	Excercises are taken as seminar. The mark in the excercises on the base 1 test - OC. Points for the quality of the solution at the test:: 0-15 - 2.0 (ndst) 16-18 - 3.0 (dst) 19-21 - 3.5 (dst+) 22-24 - 4.0 (db) 25-27- 4.5 (db+) 28-30 - 5.0 (bdb) and if each task was counted as > 4 points; The student has the right to review the results of his / her colloquium and to explain the mistakes made - in the course of the subject matter consultation; At the corrective test the student improves the tasks only from the given section, referred to items above - ie tasks rated at less than 4 points. After the corrective test for the tasks assigned to the sum of points, the number of points received * weight = 0.9; After the second corrective session, the number of points received * weight = 0.8
The final grade
Lecture	Passing the Lecture = evaluation in an exam. Exam credit OE is bases on the result of the test.: 0-21 - 2.0 (ndst) 22-26 - 3.0 (dst) 27-30 - 3.5 (dst+) 31-34 – 4.0 (db) 35-38 – 4.5 (db+) 39-40- 5.0 (bdb) Factor related to the term Exam / Credit w=1 - 1-st term; w=0.9 - 2-nd term; w=0.8 - 3rd term. w=0.8 - 3-rd term;
Class	Excercises are taken as seminar. The mark in the excercises on the base 2 tests - OC. rules as in sem. V
Laboratory	Laboratories - lab exercises performed by the group under the supervision of a teacher. The final grade from the laboratory (OL) depends on the total number of points obtained from: the written test at the end of the semester and the oral answer to the class (+0.5 point for the correct answer, -0.5 point for the wrong answer or missing). The condition for passing the laboratory is also correct execution of reports on all exercises.
The final grade	Final mark receives a credit for a course in Bioprocess Eng. .- sem (5) - according to formula: Sem. V: OK = 0,6 OW + 0,4O C

Sample problems

Required during the exam/when receiving the credit
(-)

Realized during classes/laboratories/projects
(-)

Others
(-)

Can a student use any teaching aids during the exam/when receiving the credit : yes

Available materials : 1. J. Bandrowski. M. Palica, "Materiały pomocnicze do ćwiczeń i i projektów z Inżynierii chemicznej"; 2. own lecture notes

The contents of the module are associated with the research profile: yes

1	D. Antos; W. Piątkowski	Equilibria and kinetics of ion-exchange	2024
2	D. Antos; M. Balawejder; J. Gumieniak; P. Mruc; M. Olbrycht; W. Piątkowski	Separation of non-racemic mixtures of enantiomers by achiral chromatography	2023
3	D. Antos; M. Kołodziej; W. Piątkowski; T. Rumanek	Preferential precipitation of acidic variants from monoclonal antibody pools	2023
4	D. Antos; M. Kołodziej; W. Piątkowski; T. Rumanek; P. Zimoch	Coupling of chromatography and precipitation for adjusting acidic variant content in a monoclonal antibody pool	2023
5	D. Antos; W. Piątkowski	Kinetic and Thermodynamic Aspects of Hydrophobic Interaction Chromatography	2023
6	D. Antos; A. Bajek-Bil; M. Balawejder; M. Olbrycht; W. Piątkowski	Sposób otrzymywania stereoizomeru szczawianu nafronylu o konfiguracji absolutnej (2S, 2\'R)	2021
7	D. Antos; A. Bajek-Bil; M. Balawejder; M. Olbrycht; W. Piątkowski; I. Poplewska	Development of a Route to the Most Active Nafronyl Stereoisomer by Coupling Asymmetric Synthesis and Chiral Chromatography Separation	2021
8	D. Antos; K. Baran; W. Piątkowski; A. Stańczak; P. Zimoch	Separation of charge variants of a monoclonal antibody by overloaded ion exchange chromatography	2021
9	D. Antos; P. Antos; M. Balawejder; R. Bochenek; J. Gorzelany; K. Kania; M. Kołodziej; N. Matłok; M. Olbrycht; W. Piątkowski; M. Przywara; G. Witek	Sposób wytwarzania nawozu wieloskładnikowego o kontrolowanym uwalnianiu składników	2021
10	D. Antos; W. Piątkowski; I. Poplewska	A case study of the mechanism of unfolding and aggregation of a monoclonal antibody in ion exchange chromatography	2021
11	D. Antos; G. Carta; M. Kołodziej; R. Muca; W. Piątkowski	Effects of negative and positive cooperative adsorption of proteins on hydrophobic interaction chromatography media	2020
12	D. Antos; J. Beck; A. Durauer; R. Hahn; A. Jungbauer; M. Kołodziej; W. Marek; W. Piątkowski; D. Sauer	Scale up of a chromatographic capture step for a clarified bacterial homogenate - Influence of mass transport limitation and competitive adsorption of impurities	2020
13	D. Antos; P. Antos; M. Balawejder; R. Bochenek; M. Kołodziej; N. Matłok; M. Olbrycht; W. Piątkowski; M. Przywara	Mechanism of nutrition activity of a microgranule fertilizer fortified with proteins	2020
14	D. Antos; K. Baran; W. Marek; W. Piątkowski	Effect of flow behavior in extra-column volumes on the retention pattern of proteins in a small column	2019
15	D. Antos; M. Balawejder; H. Lorenz; M. Olbrycht; W. Piątkowski; I. Poplewska; A. Seidel-Morgenstern	Cooperative Kinetic Model to Describe Crystallization in Solid Solution Forming Systems	2019
16	D. Antos; M. Kołodziej; A. Łyskowski; W. Piątkowski; I. Poplewska; P. Szałański	Determination of protein crystallization kinetics by a through-flow small-angle X-ray scattering method	2019
17	D. Antos; P. Antos; M. Balawejder; R. Bochenek; J. Gorzelany; K. Kania; M. Kołodziej; N. Matłok; M. Olbrycht; W. Piątkowski; M. Przywara; G. Witek	Sposób wytwarzania nawozu wieloskładnikowego o kontrolowanym uwalnianiu składników	2019