The aim of studying and bibliography

The main aim of study: Understanding the interactions between biologically active therapeutic agents and human genome including the genetic polymorphism

The general information about the module: The module is implemented in the second semester, includes 15 hours of lectures and 15 hours laboratory. The module ends with credit.

others: Artykuły z czasopism Trends Genet, Pharmacogenomics itp

Bibliography required to complete the module

Bibliography used during lectures

1	Prandota J.	Podstawy farmakogenetyki i farmakogenomiki w praktyce klinicznej. Jak leczyć skuteczniej i bardziej bezpiecznie	.	2003
2	Drewa G, Ferenc T.	Genetyka medyczna. Podręcznik dla studentów	Urban & Partner.	2011
3	Bal J.	Biologia molekularna w medycynie	PWN, Warszawa.	2008

Bibliography used during classes/laboratories/others

1

Instrukcje do ćwiczeń

.

Bibliography to self-study

1

Bamshad MJ, Carey C.J, Jorde L.B.

Genetyka medyczna

Urban & Partner,.

2002

Basic requirements in category knowledge/skills/social competences

Formal requirements: basic knowledge of genetics and cell biology

Basic requirements in category knowledge: Knowledge about structure of biomolecules and their interactions in the cells necessary to understand the biochemical causes of disease and drug metabolism

Basic requirements in category skills: Student mastered the use of the automatic pipette and knows the basic rules of behavior in the laboratory

Basic requirements in category social competences: Ability to cooperate as a member of team, is ethically prepared to work in field of biotechnology

Module outcomes

MEK	The student who completed the module	Types of classes / teaching methods leading to achieving a given outcome of teaching	Methods of verifying every mentioned outcome of teaching	Relationships with KEK	Relationships with PRK
01	Knowledge of the interactions between biologically active substances derived from drugs and the human genome ;	Lecture	passing practical part, paper writing	K_W06++ K_W07+++ K_U02+	P7S_UK P7S_WG
02	Is able to plan and carry out simple diagnostic procedures to detect variation in the genes responsible for drug metabolism	laboratory	written test, pasing practical part	K_U02++ K_K02++	P7S_KR P7S_UK

Attention: Depending on the epidemic situation, verification of the achieved learning outcomes specified in the study program, in particular credits and examinations at the end of specific classes, can be implemented remotely (real-time meetings).

The syllabus of the module

Sem.	TK	The content	realized in	MEK
2	TK01	Drug metabolism, individual differences in drug response, drug side effects and less effective pharmacotherapy Indications for the study of the pharmacogenetic profile of the patient, Effect of genetic polymorphism of CYP enzymes on pharmacokinetics and pharmacodynamics of drugs Consequences of CYP gene mutations Phenotypic changes specific for developmental age and diseases Genetic variants of protein transporters Binding of drugs to genetic variants of plasma proteins Glucuronazoletransferase, N-acetyltransferase, NAT2 and NAT1 (acetylator status), tiopurin S-methyltransferase (TPMT), cytochrome P450 enzymes, substrates, inhibitors and inducers Polymorphisms of markers, genes and receptors affecting drug pharmacodynamics and functional protein function, Glucocorticosteroid receptors (GR), Beta-2-adrenergic receptors (P2-AR) Use of pharmacogenetics in psychiatry, Addiction to pharmacogenomics, Pharmacogenetics in autoimmune diseases. Molecular regulation of the function of the immune system Tłumacz Google dla Firm:Narzędzia dla tłumaczyTłumacz stron	W01-W15	MEK01
2	TK02	Nomenclature of human cytochrome P450, finding and significance of mutations in pharmacogenomics (cypalleles, transformer, pharmGKB, FINDBase).Identification of biomarkers relevant for use of selected drugs. Analysis of markers for selected CYP, HLA, DNA and RNA genes	L01-L03	MEK02

The student's effort

The type of classes	The work before classes	The participation in classes	The work after classes
Lecture (sem. 2)		contact hours: 15.00 hours/sem.	Others: 6.00 hours/sem.
Laboratory (sem. 2)	The preparation for a Laboratory: 6.00 hours/sem.	contact hours: 15.00 hours/sem.
Advice (sem. 2)		The participation in Advice: 2.00 hours/sem.
Credit (sem. 2)	The preparation for a Credit: 10.00 hours/sem.	The written credit: 1.00 hours/sem.

The way of giving the component module grades and the final grade

The type of classes	The way of giving the final grade
Lecture	60% lecture
Laboratory	40%
The final grade

Sample problems

Required during the exam/when receiving the credit
(-)

Realized during classes/laboratories/projects
(-)

Others
(-)

Can a student use any teaching aids during the exam/when receiving the credit : no

The contents of the module are associated with the research profile: yes

1	B. Bakera; M. Rakoczy-Trojanowska; M. Szeliga; M. Święcicka; M. Tyrka	Identification of candidate genes responsible for chasmogamy in wheat	2023
2	P. Bednarek; A. Dorczyk; T. Drzazga; D. Jasińska; P. Krajewski; B. Ługowska; R. Martofel; P. Matysik; M. Niewińska; D. Ratajczak; K. Rączka; T. Sikora; D. Tyrka; M. Tyrka; E. Witkowski; U. Woźna-Pawlak	Genome-wide association mapping in elite winter wheat breeding for yield improvement	2023
3	M. Dyda; G. Gołębiowska; M. Rapacz; M. Szechyńska-Hebda; M. Tyrka; I. Wąsek; M. Wędzony	Quantitative trait loci and candidate genes associated with freezing tolerance of winter triticale (× Triticosecale Wittmack)	2022
4	M. Dyda; G. Gołębiowska; M. Rapacz; M. Tyrka; M. Wędzony	Genetic mapping of adult-plant resistance genes to powdery mildew in triticale	2022
5	M. Dyda; G. Gołębiowska; M. Rapacz; M. Tyrka; M. Wędzony	Mapping of QTL and candidate genes associated with powdery mildew resistance in triticale (× Triticosecale Wittm.)	2022
6	P. Krajewski; R. Marcinkowski; R. Martofel; P. Matysik; M. Mokrzycka; M. Rakoczy-Trojanowska; M. Rokicki; S. Stojałowski; M. Tyrka; U. Woźna-Pawlak; B. Żmijewska	Genome-Wide Association Analysis for Hybrid Breeding in Wheat	2022
7	A. Pietrusińska; M. Tyrka	Linkage of Lr55 wheat leaf rust resistance gene with microsatellite and DArT-based markers	2021
8	B. Bakera; P. Krajewski; M. Mokrzycka; M. Rakoczy-Trojanowska; M. Szeliga; M. Święcicka; M. Tyrka	Identification of Rf Genes in Hexaploid Wheat (Triticumaestivum L.) by RNA-Seq and Paralog Analyses	2021
9	B. Bakera; P. Krajewski; P. Matysik; M. Mokrzycka; M. Rakoczy-Trojanowska; M. Rokicki; S. Stojałowski; M. Szeliga; D. Tyrka; M. Tyrka	Evaluation of genetic structure in European wheat cultivars and advanced breeding lines using high-density genotyping-by-sequencing approach	2021
10	J. Buczkowicz; T. Drzazga; B. Ługowska; P. Matysik; K. Rubrycki; M. Semik; D. Tyrka; M. Tyrka; E. Witkowski	Identyfikacja efektywnych genów odporności na wybrane choroby wirusowe i grzybowe pszenicy zwyczajnej	2021
11	J. Buczkowicz; T. Drzazga; G. Fic; M. Jaromin; P. Krajewski; P. Matysik; R. Mazur; P. Milczarski; T. Sikora; M. Szeliga; D. Tyrka; M. Tyrka; E. Witkowski	Selekcja genomowa pszenicy ozimej	2021
12	A. Georgiadis; N. Huleyuk; M. Kurpisz; M. Olszewska; N. Pollock; T. Stokowy; A. Yatsenko; S. Yatsenko; D. Zastavna	Familial Infertility (Azoospermia and Cryptozoospermia) in Two Brothers—Carriers of t(1;7) Complex Chromosomal Rearrangement (CCR): Molecular Cytogenetic Analysis	2020
13	E. Ciszkowicz; E. Kaznowska; P. Porzycki; M. Semik; M. Tyrka	MiR-93/miR-375: Diagnostic Potential, Aggressiveness Correlation and Common Target Genes in Prostate Cancer	2020
14	G. Czajowski; M. Karbarz; M. Pojmaj; A. Strzembicka; D. Tyrka; M. Tyrka; A. Wardyńska; M. Wędzony	Quantitative trait loci mapping of adult-plant resistance to powdery mildew in triticale	2020
15	J. Ciura; M. Szeliga; M. Tyrka	Representational Difference Analysis of Transcripts Involved in Jervine Biosynthesis	2020
16	J. Ciura; M. Grzesik; M. Szeliga; M. Tyrka	Identification of candidate genes involved in steroidal alkaloids biosynthesis in organ-specific transcriptomes of Veratrum nigrum L.	2019
17	M. Dyda; M. Szechyńska-Hebda; M. Tyrka; I. Wąsek; M. Wędzony	Local and systemic regulation of PSII efficiency in triticale infected by the hemibiotrophic pathogen Microdochium nivale	2019
18	M. Dziurka; K. Hura; T. Hura; A. Ostrowska; M. Tyrka	Participation of Wheat and Rye Genome in Drought Induced Senescence in Winter Triticale (X Triticosecale Wittm.)	2019
19	M. Fraczek; N. Huleyuk; M. Kurpisz; A. Midro; M. Olszewska; E. Wiland; D. Zastavna	Chromosome (re)positioning in spermatozoa of fathers and sons - Carriers of reciprocal chromosome translocation (RCT)	2019
20	Z. Banaszak; A. Fiust; Z. Nita; W. Orłowska-Job; M. Pojmaj; M. Rapacz; M. Tyrka; M. Wójcik-Jagła	Sposób selekcji mrozoodpornych genotypów jęczmienia ozimego	2019